ARANIDIPINE
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ARANIDIPINE Eigenschaften
- Schmelzpunkt:
- 155°
- Siedepunkt:
- 530.0±50.0 °C(Predicted)
- Dichte
- 1.284±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO : 125 mg/mL (321.86 mM)
- Aggregatzustand
- Solid
- pka
- 2.56±0.70(Predicted)
- Farbe
- Light yellow to yellow
Sicherheit
Toxizit?t | LD50 in male, female mice, rats (mg/kg): 143, 193, 1982, 1459 orally; LD50 in male, female mice (mg/kg): 7.3, 9.1 i.p. (Nakano) |
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ARANIDIPINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Aranidipine was launched in Japan as an antihypertensive agent. Its pharmacological effects are similar to other dihydropyridine derivatives, e.g., nefidipine, however, it is more potent and longer lasting. This is partially due to the fact that its initial metabolite (ketone reduction) is just as effective as the parent compound. Aranidipine exerts its activity by blocking Ca+2 entry during depolarization via L-type voltagegated Ca channels. This causes decreased levels of intracellular Ca which leads to enhanced relaxation of smooth and cardiac muscle. It is a selective α2-adrenoreceptor antagonist which inhibits vasoconstrictive responses. As a dihydropyridine derivative, it can be synthesized via a modified Hantsch synthesis. While sold as a racemate, the (S)-enantiomer is 150 times more active than the (R)- antipode.ARANIDIPINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ARANIDIPINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 67)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32951 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32080 | 58 |
Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 |
1026@dideu.com | China | 7724 | 58 |
Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52849 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38470 | 58 |
PT CHEM GROUP LIMITED | |
peter68@ptchemgroup.com | China | 35425 | 58 |
LGM Pharma | 1-(800)-881-8210 |
inquiries@lgmpharma.com | United States | 2123 | 70 |
Hangzhou Yuhao Chemical Technology Co., Ltd | 0571-82693216 |
info@yuhaochemical.com | China | 9387 | 52 |
Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 |
China | 9891 | 58 |
86780-90-7()Verwandte Suche:
1,4-Dihydro-2,6-dimethyl-4-(2-ni-trophenyl)-3,5-pyridindicarbon-s?ure-dimethylester
1-sec-Butyl-2-nitrobenzol
- ARANIDIPINE
- 2,6-Dimethyl-4-(2-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid methyl 2-oxopropyl ester
- MPC-1304
- Sapresta
- 1,4-Dihydro-2,6-dimethyl-4-(2-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-methyl 5-(2-oxopropyl) ester
- Asanidipine
- 3,5-Pyridinedicarboxylicacid, 1,4-dihydro-2,6-dimethyl-4-(2-nitrophenyl)-, 3-methyl 5-(2-oxopropyl)ester
- 3-Methyl 5-(2-oxopropyl) 2,6-diMethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- Aranidipine MPC1304
- ARANIDIPINE MPC1304;MPC-1304;MPC 1304
- ARANIDIPINE USP/EP/BP
- Calcium Channel,inhibit,MPC 1304,Inhibitor,MPC-1304,Aranidipine,Ca channels,Ca2+ channels
- 86780-90-7