A971432
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- CAS-Nr.
- 1240308-45-5
- Englisch Name:
- A971432
- Synonyma:
- A971432;A971432,A 971432;A-971432 >=95% (HPLC);1-(4-((3,4-dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid;1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid;1-({4-[(3,4-dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid;3-Azetidinecarboxylic acid, 1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]-
- CBNumber:
- CB43303041
- Summenformel:
- C18H17Cl2NO3
- Molgewicht:
- 366.24
- MOL-Datei:
- 1240308-45-5.mol
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A971432 Eigenschaften
- Siedepunkt:
- 520.0±50.0 °C(Predicted)
- Dichte
- 1.402±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Slightly soluble in chloroform
- Aggregatzustand
- powder
- pka
- 2.70±0.20(Predicted)
- Farbe
- white to beige
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
A971432 Chemische Eigenschaften,Einsatz,Produktion Methoden
Biochem/physiol Actions
A-971432 is an orally bioavailable, non-clastogenic, azetidinecarboxylate compound that acts as a highly potent and selective sphingosine-1-phosphate receptor 5 agonist (IC50?= 6 nM/S1P5, 362 nM/S1P1 and >10 μM/S1P3 in a radio-ligand binding assay) without affect the activity of 129 protein kinases (IC50?>10 μM). A-971432 is shown to enhance blood-brain barrier integrity and reverse lipid accumulation and age-related cognitive decline in mice in vivo with good pharmacokinetics (t1/2??= 5.7 h; Cmax?= 2,500 ng/ml; AUC = 35,000 ng.h/ml at 10 mg/kg, p.o. in CD1 mice). Likewise, oral gavage showed good plasma exposure and no sign of lymphopenia in rats (10, 30, and 100 mg/kg.
A971432 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
A971432 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 17)Lieferanten
- A971432
- 1-[[4-[(3,4-Dichlorophenyl)methoxy]phenyl]methyl]-3-azetidinecarboxylic acid
- 1-(4-((3,4-dichlorobenzyl)oxy)benzyl)azetidine-3-carboxylic acid
- A-971432 >=95% (HPLC)
- A971432,A 971432
- 3-Azetidinecarboxylic acid, 1-[[4-[(3,4-dichlorophenyl)methoxy]phenyl]methyl]-
- 1-({4-[(3,4-dichlorophenyl)methoxy]phenyl}methyl)azetidine-3-carboxylic acid
- 1240308-45-5
