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Fezolinetant

Fezolinetant Struktur
1629229-37-3
CAS-Nr.
1629229-37-3
Englisch Name:
Fezolinetant
Synonyma:
ESN-364;Fezolinetant;Fexolinetant;Fezolinetant, 10 mM in DMSO;FEZOLINETANT; ESN-364; ESN 364; ESN364;(S)-1-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2,3-dihydro-1H-indene-4-carbonitrile;Inhibitor,Neurokinin Receptor,ESN364,Tachykinin receptor,ESN 364,Fezolinetant,inhibit,NK receptor;(R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone;Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)-
CBNumber:
CB43159873
Summenformel:
C16H15FN6OS
Molgewicht:
358.39
MOL-Datei:
1629229-37-3.mol

Fezolinetant Eigenschaften

Siedepunkt:
623.0±65.0 °C(Predicted)
Dichte
1.56±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO:20.0(Max Conc. mg/mL);55.8(Max Conc. mM)
pka
-0.28±0.40(Predicted)
Aggregatzustand
Solid
Farbe
White to yellow
InChI
InChI=1S/C16H15FN6OS/c1-9-13-19-20-14(15-18-10(2)21-25-15)23(13)8-7-22(9)16(24)11-3-5-12(17)6-4-11/h3-6,9H,7-8H2,1-2H3/t9-/m1/s1
InChIKey
PPSNFPASKFYPMN-SECBINFHSA-N
SMILES
C(N1CCN2C(C3SN=C(C)N=3)=NN=C2[C@H]1C)(C1=CC=C(F)C=C1)=O

Sicherheit

Fezolinetant Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Fezolinetant is an antagonist of the neurokinin 3 receptor (NK3R), used for the treatment of menopausal hot flushes.

Mechanism of action

Fezolinetant is an oral non-hormonal therapy that is an NK3R antagonist. It works by binding to and blocking the activity of NK3 receptors, which play a role in the regulation of body temperature in the brain.

Fezolinetant Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Fezolinetant Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 99)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shijiazhuang Dingmin Pharmaceutical Sciences Co., Ltd.
+86-0311-67591193 +8615933619867
 sales@dingminpharma.com China 253 58
S&Y Biochem Co.,Ltd
+8617774091612
 marketing@sybiochem.com China 128 58
Jinan Million Pharmaceutical Co., Ltd 		0531-68659554 +8613031714605
 info@millionpharm.com China 295 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 484 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32965 60
Jinan Carbotang Biotech Co.,Ltd. 		+8615866703830
 figo.gao@foxmail.com China 8497 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Chemtour Biotech Co., Ltd 		+8617327281506
 market@chemtour.com China 1519 58
  • ESN-364
  • FEZOLINETANT; ESN-364; ESN 364; ESN364
  • Methanone, [(8R)-5,6-dihydro-8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl](4-fluorophenyl)-
  • Inhibitor,Neurokinin Receptor,ESN364,Tachykinin receptor,ESN 364,Fezolinetant,inhibit,NK receptor
  • (R)-(4-fluorophenyl)(8-methyl-3-(3-methyl-1,2,4-thiadiazol-5-yl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone
  • Fexolinetant
  • Fezolinetant
  • (S)-1-((2-((tert-butyldimethylsilyl)oxy)ethyl)amino)-2,3-dihydro-1H-indene-4-carbonitrile
  • Fezolinetant, 10 mM in DMSO
  • 1629229-37-3
  • APIS
  • API
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