Desoxycorton Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R40:Verdacht auf krebserzeugende Wirkung.
R48:Gefahr ernster Gesundheitssch?den bei l?ngerer Exposition.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to creamy-white crystalline powder
Verwenden
A mineralocorticoid that occurs in adrenal cortex. It acts as a precursor to Aldosterone (A514700).
Definition
ChEBI: A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group.
Allgemeine Beschreibung
11-Deoxycorticosterone is a steroid hormone produced in the adrenal glands that acts as a precursor for the hormone aldosterone. Levels of 11-deoxycorticosterone are measured by LC-MS/MS to aid in diagnosing disorders of steroid synthesis, such as 11-hydroxylase deficiency and glucocorticoid responsive hyperaldosteronism. This Certified Spiking Solution
? is suitable for use as starting material inlinearity standards, calibrators, and controls for numerous LC-MS/MS applications in endocrinology, clinical chemistry, and neonatal screening.
Hazard
Toxic.
Mechanism of action
Desoxycorticosterone causes an increase in reabsorption of sodium ions and excretion
of potassium ions from the renal tubules, which leads to increased tissue hydrophilicity.
This facilitates an elevated volume of plasma and increased arterial pressure. Muscle tonicity
and work capability are increased. It is used for an insufficiency of function of the adrenal
cortex, myasthenia, asthenia, adynamia, and overall muscle weakness.
l?uterung methode
Crystallise 11-deoxycorticosterone from diethyl ether. [Schindler et al. Helv Chim Acta 24 360 1941, Steiger & Reichstein Helv Chim Acta 20 1164 1937.]
Desoxycorton Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
