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MS37452

MS37452 Struktur
423748-02-1
CAS-Nr.
423748-02-1
Englisch Name:
MS37452
Synonyma:
MS37452;MS37452, 10 mM in DMSO;1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine;1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone;1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone;Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-;1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethan-1-one;MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452
CBNumber:
CB43060612
Summenformel:
C22H26N2O5
Molgewicht:
398.45224
MOL-Datei:
423748-02-1.mol

MS37452 Eigenschaften

Siedepunkt:
628.8±55.0 °C(Predicted)
Dichte
1.209±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
pka
-1.31±0.70(Predicted)
Aggregatzustand
powder
Farbe
white to beige

Sicherheit

MS37452 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Chromobox homolog 7 (CBX7) functions through its N-terminal chromodomain, which recognizes histone 3 trimethyl lysine 27 (H3K27me3), to repress gene transcription. It plays a key role in gene transcription in cellular processes related to stem cell self-renewal and differentiation, as well as tumor progression. MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 (Ki = 43 μM). At 250 μM, it has been shown to derepress transcription of the polycomb repressive complex target gene p16/CDKN2A in prostate cancer cells.

Verwenden

MS37452 is a competitive inhibitor of CBX7 chromodomain binding to H3K27me3 and has been shown to derepress transcription of the polycomb repressive complex target gene.

Biochem/physiol Actions

MS37452 is a selective Chromobox homolog 7 (CBX7) modulator that disrupts CBX7ChD binding to H3K27me3. MS37452 inhibits CBX7 binding to INK4/ARF gene locus, and induces decline of p14/ARF and p16/INK4a in human PC3 cells.

MS37452 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

MS37452 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 49)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4573 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Shanghai Changyan Chem & Tech Co., Ltd. 021-20242659 18930833303
 Sales@changyanchem.cn China 5010 55
Beijing OKA biological technology co., LTD 010-010-010-62971590 18548936886
 jack@oka-vip.com China 6897 58
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9409 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767
 sales@chemegen.com China 11218 58
Absin Bioscience Inc. 021-38015121 15000105423
 wulan@absin.cn China 24731 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
  • MS37452
  • 1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine
  • Ethanone, 1-[4-(2,3-dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-
  • 1-(4-(2,3-Dimethoxybenzoyl)piperazin-1-yl)-2-(m-tolyloxy)ethanone
  • 1-[4-(2,3-Dimethoxybenzoyl)-1-piperazinyl]-2-(3-methylphenoxy)-ethanone
  • MS 37452,Histone Methyltransferase,transcription,Inhibitor,MS37452,p16/CDKN2A,anticancer,H3K27me3,derepress,CBX7 chromodomain,inhibit,INK4A/ARF,MS-37452
  • 1-[4-(2,3-dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethan-1-one
  • MS37452, 10 mM in DMSO
  • 423748-02-1
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