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PFK-158

PFK-158 Struktur
1462249-75-7
CAS-Nr.
1462249-75-7
Englisch Name:
PFK-158
Synonyma:
PFK-158;PFK-158;PFK 158;PFK-158 free base;PFK-158, ACT-PFK-158;(E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one;(2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one;(E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one;2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-;p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
CBNumber:
CB43034954
Summenformel:
C18H11F3N2O
Molgewicht:
328.29
MOL-Datei:
1462249-75-7.mol

PFK-158 Eigenschaften

Siedepunkt:
466.3±45.0 °C(Predicted)
Dichte
1.346±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMSO:14.0(Max Conc. mg/mL);42.6(Max Conc. mM)
Aggregatzustand
A crystalline solid
pka
2.46±0.10(Predicted)
Farbe
White to light yellow

Sicherheit

PFK-158 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

PFK158 is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 (PFKFB3; IC50 = 137 nM for human recombinant PFKFB3). It inhibits PFKFB3 and glycolysis in Jurkat cells (IC50s = 1.6 and 0.847 μM, respectively). PFK158 inhibits the growth of leukemia cells in vitro (IC50 = 0.33 μM for Jurkat cells) and reduces tumor volume in CT-26 murine colon carcinoma syngeneic model and a BxPC-3 pancreatic cancer mouse xenograft model. PFK158 also enhances activity of the anti-CTLA-4 antibody in the B16/F10 mouse model of melanoma.

PFK-158 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PFK-158 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 65)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10311 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471
 sales@sarms4muscle.com China 10473 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Hebei Miaoyin Technology Co.,Ltd 		+86-17367732028 +86-17367732028
 kathy@hbyinsheng.com China 3512 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58

1462249-75-7()Verwandte Suche:

  • PFK-158
  • PFK-158, ACT-PFK-158
  • (2E)-1-(4-Pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-2-propen-1-one
  • PFK-158;PFK 158
  • PFK-158 free base
  • 2-Propen-1-one, 1-(4-pyridinyl)-3-[7-(trifluoromethyl)-2-quinolinyl]-, (2E)-
  • (E)-1-(Pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one
  • p-cPLA2,inhibit,anti-proliferative,Autophagy,PFK 158,LC3BII,glycolysis,Inhibitor,PFK158,anti-tumor,PFK-158,Apoptosis,lactate,PFKFB3
  • (E)-1-(4-Pyridyl)-3-[7-(trifluoromethyl)-2-quinolyl]-2-propen-1-one
  • 1462249-75-7
  • 1462249-75-1
  • C18H11F3N2O
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