Indoprofen
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- CAS-Nr.
- 31842-01-0
- Bezeichnung:
- Indoprofen
- Englisch Name:
- ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
- Synonyma:
- k4277;flosin;Praxis;flosint;Bor-ind;Reumofe;isindone;Reumofene;INDOPROFEN;Aids025462
- CBNumber:
- CB4297426
- Summenformel:
- C17H15NO3
- Molgewicht:
- 281.31
- MOL-Datei:
- 31842-01-0.mol
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Indoprofen Eigenschaften
- Schmelzpunkt:
- 213-214°
- Siedepunkt:
- 423.97°C (rough estimate)
- Dichte
- 1.1302 (rough estimate)
- Brechungsindex
- 1.4500 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- pKa 5.8 (Uncertain)
- Farbe
- White to off-white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25-40 |
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| S-S?tze: |
22-36/37/39-45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| RTECS-Nr. |
MU6645000 |
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| Toxizit?t |
LD50 in rats (mg/kg): 58.66 i.v.; 60.83 orally (Buttinoni) |
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| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
| H351 |
Kann vermutlich Krebs verursachen. |
Karzinogenit?t |
Kategorie 2 |
Warnung |
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P201, P202, P281, P308+P313, P405,P501 |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
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Indoprofen Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R25:Giftig beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
Chemische Eigenschaften
ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is Off-White Solid
Verwenden
ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID is a non-steroidal anti-inflammatory agent used for treatment of pain and inflammation
Definition
ChEBI: A monocarboxylic acid that is propionic acid in which one of the hydrogens at position 2 is substituted by a 4-(1-oxo-1,3-dihydroisoindol-2-yl)phenyl group. Initially used as an anti-inflammatory and analgesic, it was withdrawn from the market due to causi
g severe gastrointestinal bleeding. It has been subsequently found to increase production of the survival motor neuron protein.
Weltgesundheitsorganisation (WHO)
Indoprofen, a nonsteroidal anti-inflammatory agent, was
introduced in 1976 for the treatment of rheumatic disorders. By 1983 its use had
been associated with serious adverse effects, some of which were fatal. This led to
its withdrawal in the United Kingdom and Cyprus. In 1984 reports of intestinal
tumours in rats led to the drug's temporary withdrawal in Germany and Italy. This
was followed immediately by the suspension of marketing worldwide by the major
manufacturer.
Indoprofen Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Ethyl 2-chloromethylbenzoate
Kaliumhydroxid
Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-, ethyl ester
Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-, methyl ester
Benzeneacetic acid, 4-(1,3-dihydro-2H-isoindol-2-yl)-α-methyl-, ethyl ester
1H-Isoindol-1-one, 2-(4-chlorophenyl)-2,3-dihydro-
4-Aminohydratropasure
Ethyl-2-(4-aminophenyl)propionat
2-(4-Nitrophenyl)propionsure
Ethyl-2-(4-nitrophenyl)propionat
Zink
carbon monoxide
Kohlenstoffdioxid
Phthalaldehydsure
Downstream Produkte
Indoprofen Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 80)Lieferanten
31842-01-0(Indoprofen)Verwandte Suche:
- ALPHA-METHYL-P-[1-OXO-2-ISOINDOLINYL]-BENZENEACETIC ACID
- 1-oxo-2-(p-((alpha-methyl)carboxymethyl)phenyl)isoindoline
- 2-(4-(1-carboxyethyl)phenyl)-1-isoindolinone
- 2-(p-(1-oxo-2-isoindolinyl)phenyl)-propionicaci
- 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methyl-benzeneaceticaci
- 4-(1,3-dihydro-1-oxo-2h-isoindol-2-yl)-alpha-methylbenzeneaceticacid
- alpha-(4-(1-oxo-2-isoindolinyl)phenyl)-propionicaci
- alpha-(4-(1-oxo-2-iso-indolinyl)-phenyl)-propionicacid
- flosin
- INDOPROFEN
- flosint
- isindone
- k4277
- p-(1-oxo-2-isoindolinyl)-hydratropicaci
- p-(1-oxo-2-isoindolinyl)-hydratropicacid
- α-methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid
- 1-Oxo-2-[p-[(a-methyl)carboxymethyl]phenyl]isoindoline
- 2-[4-(1-Oxo-2-isoindolinyl)phenyl]propanoic Acid
- 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-a-methylbenzeneacetic Acid
- Bor-ind
- Praxis
- Reumofe
- Indoprofen Solution, 100ppm
- 2-[p-(1-Oxo-2-isoindolinyl)phenyl]propionic acid
- 4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-methylbenzeneacetic acid
- Aids025462
- Aids-025462
- Reumofene
- Indoprofen,α-Methyl-p-(1-oxo-2-isoindolinyl)benzeneacetic acid
- 2-(4-(1-oxoisoindolin-2-yl)phenyl)propanoic acid
- (+/-) Indoprof
- 1-Oxo-2-[p-[(α-Methyl)carboxyMethyl]phenyl]isoindoline
- Benzeneacetic acid, 4-(1,3-dihydro-1-oxo-2H-isoindol-2-yl)-α-methyl-
- (±)-Indoprofe
- inhibit,Indoprofen,Inhibitor
- Indoprofen Indoprofen
- 31842-01-0
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