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N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Struktur
211311-95-4
CAS-Nr.
211311-95-4
Englisch Name:
N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
Synonyma:
100775;CS-2739;LY40418;LY404187;LY-404187; LY 404187;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide;N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide;N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide;N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide;N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
CBNumber:
CB42640286
Summenformel:
C19H22N2O2S
Molgewicht:
342.46
MOL-Datei:
211311-95-4.mol

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Eigenschaften

Siedepunkt:
519.0±60.0 °C(Predicted)
Dichte
1.19±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMF: 15mg/mL; DMSO: 15mg/mL; DMSO:PBS (pH 7.2) (1:4): 0.2mg/mL; Ethanol: 3mg/mL
Aggregatzustand
A solid
pka
11.24±0.40(Predicted)
Farbe
White to off-white

Sicherheit

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

LY404187 is a benzothiadiazide positive allosteric modulator of AMPA receptors. It increases glutamate-induced activation of GluR1i, -2i, -2o, -3i, and -4i subunit-containing AMPA receptors with EC50 values of 5.65, 0.15, 1.44, 1.66, and 0.21 μM, respectively, in a calcium influx assay. LY404187 is selective for these AMPA receptors over GluR6 subunit-containing kainate receptors at 10 μM. LY404187 increases currents induced by glutamate and AMPA in rat prefrontal cortex pyramidal neurons (EC50s = 1.3 and 1.2 μM, respectively) but not in AMPA-stimulated primary rat embryonic hippocampal or primary cerebellar Purkinje neurons. LY404187 prevents decreases in the number of dopaminergic neurons in the substantia nigra induced by MPTP and 6-OHDA in mouse and rat, respectively, models of Parkinson’s disease when administered at a dose of 0.5 mg/kg per day.

Verwenden

LY 404187 is a novel positive allosteric modulator of AMPA receptors.

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 67)Lieferanten
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30239 58
InvivoChem 		+1-708-310-1919 +1-13798911105
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TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
ChemShuttle, Inc. 0510-83588313-802 18800520310;
 sales@chemshuttle.com China 3002 62
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2782 58
CEG Chemical Science&Technology Co., Ltd. Mobile:13665161512
China 1785 58

211311-95-4()Verwandte Suche:

  • N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
  • LY404187
  • N-(2-(4'-Cyano-[1,1'-biphenyl]-4-yl)propyl)propane-2-sulfonaMide
  • N-[2-(4'-Cyano[1,1'-biphenyl]-4-yl)propyl]-2-propanesulfonamide
  • N-2-(4-(4-Cyanophenyl)phenyl)propyl-2-propanesulfonamide
  • LY-404187 N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonaMide
  • CS-2739
  • 100775
  • LY-404187; LY 404187
  • 2-Propanesulfonamide, N-[2-(4'-cyano[1,1'-biphenyl]-4-yl)propyl]-
  • N-[2-[4-(4-Cyanophenyl)phenyl]propyl]propane-2-sulfonamide
  • GluR2o,inhibit,Allosteric,GluR3i,iGluR,GluR4i,AMPA,Ionotropic glutamate receptors,GluR1i,LY-404187,psychiatric,LY404187,Inhibitor,GluR2i,LY 404187,neurodegenerative
  • LY40418
  • N-(2-(4'-cyanobiphenyl-4-yl)propyl)propane-2-sulfonamide
  • 211311-95-4
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