BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P308+P313
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P314
Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen.
P405
Unter Verschluss aufbewahren.
P501
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut. R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren. S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Lipitor was launched in Canada, the Netherlands, the UK and the US as an
orally-active hypocholesterolemic agent. It was the first pharmaceutical product ever
to attain over one billion dollars in sales in its first year. It can be synthesized by a
number of routes but the most efficient involves the Paal-Knorr reaction of an
acetonide protected dihydroxy amino ester and a diaryl phenylacetamide diketone.
Lipitor is a liver selective, reversible competitive inhibitor of HMG-CoA reductase, the
rate limiting step in cholesterol biosynthesis. Lipitor monotherapy resulted in a
reduction of LDL cholesterol by up to 60%. Lipitor is about 2-4 times more potent, on
a dosage basis, than Simvastatin. The superior properties of Lipitor can be attributed
to its greater uptake and longer duration of action in the liver. In addition to its effects
on cholesterol, Lipitor is also effective in lowering triglycerides. While the mechanism
is not clear, two theories proposed are: a) the decrease in cholesterol causes a
concomitant increase in hepatic LDL-receptor activity (mostly B and E type) which
results in a decrease in triglycerides through an increase in binding of triglycerides to
VLDL and LDL, and b) the decreased level of cholesterol impairs VLDL transport of
triglycerides.
Chemische Eigenschaften
White Crystalline Powder
Verwenden
A selective, competitive HMG-CoA reductase inhibitor. The only drug in its class specfically indicated for lowering both elevated LDL-cholesterol and triglycerides in patients with hypercholesterolemia
Definition
ChEBI: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Biologische Aktivit?t
Potent HMG-CoA reductase inhibitor (IC 50 = 8 nM). Reduces circulating LDL-C by inhibiting cholesterol biosynthesis and inducing expression of LDL receptors. Inhibits smooth muscle cell proliferation in vitro and exhibits antinociceptive effects in the inflammatory hypernociception model.
Atorvastatin calcium Upstream-Materialien And Downstream Produkte