HTS 01037 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Adipocyte fatty acid binding protein (A-
FABP/aP2) is a carrier protein expressed in both adipocytes and macrophages where it functions in intracellular fatty acid solubilization, trafficking, and metabolism. Molecular disruption of A-
FABP/aP2 in mice results in improved insulin sensitivity and protection from atherosclerosis. HTS 01037 is a high-
affinity ligand of adipocyte fatty acid binding protein (A-
FABP/aP2) (K
i = 0.67 μM) that presumably competes with fatty acids for functional binding in the ligand-
binding cavity of A-
FABP/aP2. At a concentration of 10 μM, HTS 01037 antagonizes the protein-
protein interaction of A-
FABP/aP2 with hormone sensitive lipase in cultured C8PA lipocytes. HTS 01037 inhibits lipolysis in 3T3L1 adipocytes and reduces lipopolysaccharide-
stimulated inflammation in bone marrow-
derived macrophages, both effects of which are similar to the phenotype of A-
FABP/aP2 knockout mice.
Verwenden
HTS 01037 is an inhibitor of fatty acid binding protein and a competitive antagonist of protein-protein interactions mediated by AFABP/aP2.
HTS 01037 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
