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SU 16f

SU 16f Struktur
251356-45-3
CAS-Nr.
251356-45-3
Englisch Name:
SU 16f
Synonyma:
SU 16f;PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem;(Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid;5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid;1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-;3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
CBNumber:
CB42501833
Summenformel:
C24H22N2O3
Molgewicht:
386.44
MOL-Datei:
251356-45-3.mol

SU 16f Eigenschaften

Siedepunkt:
661.7±55.0 °C(Predicted)
Dichte
1.292±0.06 g/cm3(Predicted)
storage temp. 
Store at RT
L?slichkeit
Soluble to 100 mM in DMSO
Aggregatzustand
Dark orange solid
pka
4?+-.0.10(Predicted)
Farbe
Yellow to orange

Sicherheit

SU 16f Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

SU 16f is used in the synthetic preparation of [(Dihydrooxoindolylidene)methyl]pyrrolepropanoic Acid as a tyrosine kinase inhibitor.

Allgemeine Beschreibung

A cell-permeable indolinone compound that acts as a potent, ATP site-targeting PDGFR inhibitor (IC50 = 10 nM against PDGFRβ), while affecting Flk-1/KDR/ VEGFR2, FGFR1, and EGFR only at much higher concentrations (IC50 = 0.14, 2.29, and >100 μM, respectively). Reported to selectively inhibit PDGFβ- over EGF-stimulated proliferation in EGFR-expressing NIH 3T3 cultures (IC50 = 0.11 and 21.9 μM, respectively) and exhibit much weaker potency against the proliferation of HUVEC cells upon FGF or VEGF stimulation (IC50 = 10 μM).

SU 16f Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SU 16f Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 57)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30238 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
Sigma-Aldrich 021-61415566 800-8193336
 orderCN@merckgroup.com China 51456 80
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4575 55
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
  • 5-[1,2-Dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoicacid
  • (Z)-3-(2,4-Dimethyl-5-((2-oxo-6-phenylindolin-3-ylidene)methyl)-1H-pyrrol-3-yl)propanoic acid
  • SU 16f
  • PDGFR Tyrosine Kinase Inhibitor VII - CAS 251356-45-3 - Calbiochem
  • 1H-Pyrrole-3-propanoic acid, 5-[(1,2-dihydro-2-oxo-6-phenyl-3H-indol-3-ylidene)methyl]-2,4-dimethyl-
  • 3-{2,4-dimethyl-5-[(2-oxo-6-phenyl-2,3-dihydro-1H-indol-3-ylidene)methyl]-1H-pyrrol-3-yl}propanoic acid
  • 251356-45-3
  • Angiogenesis and Metastasis
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