Cimetidin Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R60:Kann die Fortpflanzungsf?higkeit beeintr?chtigen.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/22:Gesundheitssch?dlich beim Einatmen und Verschlucken.
S-S?tze Betriebsanweisung:
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S22:Staub nicht einatmen.
Beschreibung
Cimetidine is a representative of first-generation antihistamine drugs that block H2 receptors.
Chemische Eigenschaften
White Solid
Verwenden
Cimetidine is used for treating ulcer problems of the stomach and duodenum and for
other conditions accompanied by an elevation of acidity and excess secretion of gastric
juice. It is used for preventing injuries and the blood flow of the upper regions of the gastrointestinal tract.
Indications
Cimetidine, the first released H2-blocker, like histamine,
contains an imidazole ring structure. It is well absorbed
following oral administration, with peak blood
levels 45 to 90 minutes after drug ingestion. Blood levels
remain within therapeutic concentrations for approximately
4 hours after a 300-mg dose. Following oral
administration, 50 to 75% of the parent compound is
excreted unchanged in the urine; the rest appears primarily
as the sulfoxide metabolite.
Definition
ChEBI: A member of the class of guanidines that consists of guanidine carrying a methyl substituent at position 1, a cyano group at position 2 and a 2-{[(5-methyl-1H-imidazol-4-yl)methyl]sulfanyl}ethyl group at position 3. It is a H
-receptor antagonist that inhibits the production of acid in stomach.
Allgemeine Beschreibung
White crystals with a slight sulfur-mercaptan odor.
Air & Water Reaktionen
Slightly water soluble.
Brandgefahr
Flash point data for Cimetidine are not available. Cimetidine is probably combustible.
Biologische Aktivit?t
Widely used H 2 histamine antagonist which has more recently been described as an inverse agonist. Also a potent I 1 imidazoline binding site ligand.
Pharmakologie
The main pharmacological effect of cimetidine is the suppression of gastric juice
secretion associated with H2 receptors of the stomach walls. It suppresses both basal and
stimulated hydrochloric acid produced by food as well as histamine and gastrine, which
simultaneously lower pepsin activity.
Nebenwirkungen
Cimetidine may infrequently cause diarrhea, nausea,
vomiting, or mental confusion. A rare association
with granulocytopenia, thrombocytopenia, and pancytopenia
has been reported. Gynecomastia has been
demonstrated in patients receiving either high-dose or
long-term therapy.
Cimetidin Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
