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(S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat

1,2-DIPALMITOYL-SN-GLYCEROL Struktur
30334-71-5
CAS-Nr.
30334-71-5
Bezeichnung:
(S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat
Englisch Name:
1,2-DIPALMITOYL-SN-GLYCEROL
Synonyma:
DPG;(S)-3-Hydroxypropane-1,2-diyl dipalmitate;1,2-DIPALMITIN;DG(16:0/16:0/0:0);16:0 DG;NSC 269964;Einecs 250-131-4;D-a,b-DipalMitin;sn-1,2-DipalMitin;(S)-1,2-DIPALMITIN
CBNumber:
CB4228240
Summenformel:
C35H68O5
Molgewicht:
568.91
MOL-Datei:
30334-71-5.mol

(S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat Eigenschaften

Schmelzpunkt:
66-69 °C
Siedepunkt:
620.8±22.0 °C(Predicted)
Dichte
0.930±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMF: 20 mg/ml; DMSO: 5 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .25 mg/ml
Aggregatzustand
A crystalline solid
pka
13.69±0.10(Predicted)
Farbe
White to off-white
BRN 
1730209
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  1
10
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H331 Giftig bei Einatmen. Akute Toxizit?t inhalativ Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P261, P271, P304+P340, P311, P321,P403+P233, P405, P501
H336 Kann Schl?frigkeit und Benommenheit verursachen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Schl?frigkeit und Benommenheit) Warnung P261, P271, P304+P340, P312,P403+P233, P405, P501
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
H372 Sch?digt bei Hautkontakt und Verschlucken die Organe bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P260, P264, P270, P314, P501
H412 Sch?dlich für Wasserorganismen, mit langfristiger Wirkung. Langfristig (chronisch) gew?ssergef?hrdend Kategorie 3 P273, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P273 Freisetzung in die Umwelt vermeiden.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

(S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

1,2-Dipalmitoyl-sn-glycerol (1,2-DPG) is an analog of the protein kinase C (PKC)-activating second messenger diacylglycerol. 1,2-Dipalmitoyl-sn-glycerol is a weak activator of PKC.

Definition

ChEBI: A 1,2-diacyl-sn-glycerol in which both acyl groups are specified as palmitoyl (hexadecanoyl).

Allgemeine Beschreibung

In biochemical signaling, diacylglycerol (DAG) functions as a second messenger signaling lipid, and is a product of the hydrolysis of the phospholipid PIP2 (phosphatidylinositolbisphosphate) by the enzyme phospholipase C (PLC) (a membrane-bound enzyme) that, through the same reaction, produces inositol trisphosphate (IP3). Although inositol trisphosphate (IP3) diffuses into the cytosol, DAG remains within the plasma membrane due to its hydrophobic properties. IP3 stimulates the release of calcium ions from the smooth endoplasmic reticulum, whereas DAG is a physiological activator of protein kinase C (PKC). The production of DAG in the membrane facilitates translocation of PKC from the cytosol to the plasma membrane.
Diacylglycerol mimicks the effects of the tumor-promoting compounds phorbol esters.

l?uterung methode

Crystallise S(-)-1,2-dipalmitin from chloroform/pet ether (b 40-60o) ~1:1.5. [S(-)-isomer: Baer & Kates J Am Chem Soc 72 942 1950, Hanahan & Vercamer J Am Chem Soc 7 6 1804 1954, R(+)-isomer: Tattrie et al. Arch Biochem 78 319 1958, Beilstein 2 IV 1173.] The racemate [40290-32-2] is polymorphic with different IR spectra. When crystallised from hexane, or other solvents, the higher melting form with m 71.5-72.5o is obtained. The melt then solidifies to give the lower melting -form with m 49.7-50o. The -form has m 61o (65-66o is also reported). When the lower melting forms are kept at their melting temperatures for a while, they are converted to the higher melting form. [Howe & Malkin J Chem Soc 2663 1951, Baer & Kates J Am Chem Soc 72 942 1950, Beilstein 2 IV 1173.]

(S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 91)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3958 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32070 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58
Nextpeptide Inc
+86-0571-81612335 +8613336028439
sales@nextpeptide.com China 19908 58
Alfa Chemistry

Info@alfa-chemistry.com United States 24072 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38463 58
PT CHEM GROUP LIMITED

peter68@ptchemgroup.com China 35425 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490
info@gihichemicals.com China 49979 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20288 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58

30334-71-5((S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat)Verwandte Suche:


  • D-ALPHA,BETA-DIPALMITIN
  • L-1,2-DIPALMITOYLGLYCEROL
  • 16:0 DG
  • 1,2-DIPALMITOYL-SN-GLYCEROL
  • 1,2-DIPALMITOYL-SN-3-GLYCEROL
  • 1,2-DIHEXADECANOYL-SN-GLYCEROL
  • (S)-1,2-DIPALMITIN
  • (S)-GLYCEROL 1,2-DIPALMITATE
  • (S)-1-(hydroxymethyl)ethane-1,2-diyl dipalmitate
  • 1,2-DIPALMITOYL-SN-GLYCEROL (C16:0)
  • (S)-1-(Hydroxymethyl)ethan-1,2-diyldipalmitat
  • L-1,2-DIPALMITOYLGLYCEROL synthetic
  • Einecs 250-131-4
  • 1,2-Di-O-palMitoyl-sn-glycerol
  • Hexadecanoic Acid 1,1'-[(1S)-1-(HydroxyMethyl)-1,2-ethanediyl] Ester
  • NSC 269964
  • sn-1,2-DipalMitin
  • D-a,b-DipalMitin
  • (S)-1,2-Dipalmitin, (S)-Glycerol 1,2-dipalmitate, 1,2-Dihexadecanoyl-sn-glycerol
  • (-)-L-1,2-Dipalmitin
  • (S)-Propane-1,2,3-triol 1,2-dipalmitate
  • 1-O,2-O-Dipalmitoyl-L-glycerol
  • Bishexadecanoic acid (S)-3-hydroxypropane-1,2-diyl ester
  • Bispalmitic acid (S)-3-hydroxypropane-1,2-diyl ester
  • (-)-1,2-di-O-hexadecanoyl-sn-glycerol
  • DipalMitoyl-sn-glycerol L-0016
  • 1,2-DIPALMITOYL-SN-GLYCEROL, >=99%
  • 1,2-Dipalmitin-sn-glycerol
  • DPG
  • 1,2-DIPALMITIN
  • DG(16:0/16:0/0:0)
  • (S)-3-Hydroxypropane-1,2-diyl dipalmitate
  • Endogenous Metabolite,1,2Dipalmitoylsnglycerol,1,2 Dipalmitoyl sn glycerol,inhibit,Inhibitor
  • (2S)-2-hexadecanoyloxy-3-hydroxypropyl] hexadecanoate
  • 30334-71-5
  • Neutral Glycerides
  • Lipids
  • Glycerides
  • Diradylglycerols
  • Biochemicals and Reagents
  • BioChemical
  • Fatty & Aliphatic Acids, Esters, Alcohols & Derivatives
  • Aliphatics
  • Fatty Acid Derivatives & Lipids
  • Glycerols
  • Protein Kinase Inhibitors and Activators
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