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LEUROSINE

LEUROSINE Struktur
23360-92-1
CAS-Nr.
23360-92-1
Englisch Name:
LEUROSINE
Synonyma:
amotin;LEUROSINE;nsc-528004;Vinleurosine;Vincristine EP Impurity F;Vincristine EP Impurity F (Leurosine);4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI;(3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine;Vincristine Impurity 6(Vincristine EP Impurity F);4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
CBNumber:
CB4205283
Summenformel:
C46H56N4O9
Molgewicht:
808.97
MOL-Datei:
23360-92-1.mol

LEUROSINE Eigenschaften

Schmelzpunkt:
202-205℃
Dichte
1.39
pka
11.36±0.60(Predicted)

Sicherheit

RIDADR  1544
HazardClass  6.1(a)
PackingGroup  II
Giftige Stoffe Daten 23360-92-1(Hazardous Substances Data)
Toxizit?t dog,LDLo,intraperitoneal,12mg/kg (12mg/kg),GASTROINTESTINAL: NAUSEA OR VOMITINGGASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA",Eksperimental'naya Onkologiya. Experimental Oncology. Vol. 9(5), Pg. 76, 1987.

LEUROSINE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Vinqa rosea yields this complex dimeric alkaloid which forms colourless crystals that are best purified by recrystallization from acetonitrile. It crystallizes with 8 moles of H20 and loses solvent when heated at In-5°C. It is also dextro? rotatory with [α]26D + n° (CHCI3)’ A crystalline SUlphate is known which has m.p. 238-242°C (dec.) and [α]D - 8.3° (MeOH). The N(b)-oxide is identical with pleurosine (q.v.).

Verwenden

Vinleurosine is an antitumor compound derived from Vinca Rosea.

Einzelnachweise

Svoboda., J. Amer. Pharm. Assoc., 47,834 (1959)
Neuss et al., J. Amer. Chern. Soc., 81,4754 (1959)
Revised structure:
Neuss et al., Tetrahedron Lett., 783 (1968)

LEUROSINE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


LEUROSINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 63)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9511 58
Standardpharm Co. Ltd.
86-714-3992388
overseasales1@yongstandards.com United States 14332 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
China National Standard Pharmaceutical Corporation Limited
+8615391658522
overseasales@yongstandards.com China 11922 58
Guangzhou CATO Research Chemicals Inc.
+86-020-81960175-617 +8615602392859
Intermediate@cato-chem.com China 8322 58
QUALITY CONTROL SOLUTIONS LTD.
0755-66853366; 13670046396
ORDERS@QCSRM.COM China 24342 58
Hubei Moco Chemical Co., Ltd. 18627753421 18627756402
3001009495@qq.com China 19063 58
ChemStrong Scientific Co.,Ltd 0755-0755-66853366 13670046396
sales@chem-strong.com China 18070 56

23360-92-1()Verwandte Suche:


  • Vinleurosine
  • 4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
  • (3'R,4'S)-3',4'-Oxy-4'-deoxyvincaleukoblastine
  • (3'alpha,4'alpha)-4'-Deoxy-3',4'-epoxyvincaleukoblastine
  • 4'-Deoxy-3',4'-epoxyvincaleucoblastine, 9CI
  • 4’-deoxy-3’,4’-epoxy-,(3’-alpha,4’-alpha)-vincaleukoblastin
  • 4’-deoxy-3’,4’-epoxy-,(3’alpha,4’alpha)-vincaleukoblastin
  • amotin
  • LEUROSINE
  • nsc-528004
  • Vincristine Impurity 6(Vincristine EP Impurity F)
  • Vincaleukoblastine,4'-deoxy-3',4'-epoxy-, (3'a,4'a)-
  • Vincaleukoblastine, 4'-deoxy-3',4'-epoxy-, (3'α,4'α)-
  • Vincristine EP Impurity F
  • Vinorelbine EP Impurity E/Leurosine/4b-Acetoxy-3,4epoxy-3-hydroxy-16-methoxy-(4 H)-vincaleukoblast-6-ene-23,22dioic Acid Dimethyl Ester
  • Vincristine EP Impurity F (Leurosine)
  • 4′-deoxy-3′α,4′α-epoxyvincaleukoblastine(leurosine)
  • methyl(3aR,4R,5S,5aR,10bR,13aR)-4-(acetyloxy)-3a-ethyl-9-[(1aS,11S,13S,13aR)-1a-ethyl-11-(methoxycarbonyl)-1a,4,5,10,11,12,13,13a-octahydro-2H-3,13-methano-oxireno[9,10]azacycloundecino[5,4-b]indol-11-yl]-5-hydroxy-8-methoxy-6-methyl-3a,4,5,5a,6,11,12,13a-octahydro-1H-indolizino[8,1-cd]carbazole-5-carboxylate(leurosine)
  • Vincristine EP Impurity F(Vinorelbine EP Impurity E)
  • 23360-92-1
  • C46H58N4O13S
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