SL 327
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- CAS-Nr.
- 305350-87-2
- Englisch Name:
- SL 327
- Synonyma:
- SL 327;CS-1890;SL 327; SL-327;SL 327 USP/EP/BP;MEK Inhibitor VII;SL327, 10 mM in DMSO;Mek-1/Mek-2 Inhibitor;SL 327, MEK inhibitor;MEK Inhibitor VII SL327 SL-327;SL327;SL-327;MEK-1/MEK-2 INHIBITOR
- CBNumber:
- CB4168773
- Summenformel:
- C16H12F3N3S
- Molgewicht:
- 335.35
- MOL-Datei:
- 305350-87-2.mol
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SL 327 Eigenschaften
- Schmelzpunkt:
- 127-128.2 °C
- Siedepunkt:
- 512.6±50.0 °C(Predicted)
- Dichte
- 1.40
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 32 mg/mL
- Aggregatzustand
- solid
- pka
- 3.42±0.10(Predicted)
- Farbe
- white
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| WGK Germany |
3 |
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| HS Code |
2930909899 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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SL 327 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The dual specific threonine/tyrosine kinase MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates a diverse array of cellular processes. SL 327 is an inhibitor of MEK1 and MEK2 (IC
50s = 0.18 and 0.22 μM), the kinases upstream of ERK1/2. It inhibits ERK1, MKK/p38, MKK4, JNK, and PKC at much higher concentrations (IC
50s = >50, 21, >100, >100, >10 μM, respectively). Since SL 327 rapidly passes the blood-
brain barrier, it has been used to dissect the effect of RAS/RAF/MEK/ERK signaling pathway inhibition on behavior, including long-term memory, spatial learning, and fear/operant conditioning.
Verwenden
SL-327 is a selective inhibitor of MEK1 and MEK2, and ERK1, MEK-3/p38, MEK-4, JNK, and PKC at higher concentrations.
Definition
ChEBI: A nitrile that is acrylonitrile in which the hydrogen attached to the same carbon as the cyano group has been replaced by an o-(trifluoromethyl)phenyl group, while the remaining hydrogens of the ethenyl group have been replaced by amino and (4
aminophenyl)sulfanyl groups. The configuration of the double bond is not specified. It is an inhibitor of MEK1 and MEK2.
Biologische Aktivit?t
Selective inhibitor of MEK1 and MEK2 (IC 50 values are 0.18 and 0.22 μ M respectively); blocks hippocampal LTP in vitro . Brain penetrant in vivo , blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
SL 327 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
SL 327 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 143)Lieferanten
305350-87-2()Verwandte Suche:
- ALPHA-[AMINO[(4-AMINOPHENYL)THIO]METHYLENE]-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
- ALPHA-[AMINO-(4-AMINOPHENYLTHIO)METHYLENE)-2-(TRIFLUOROMETHYL)PHENYLACETONITRILE
- SL 327
- Z-EPSILON-T E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
- Z-AND E-ALPHA-(AMINO-((4-AMINOPHENYL)THIO)METHYLENE)-2-(TRIFLUOROMETHYL)BENZENEACETONITRILE
- a-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
- α-[amino-(4-aminophenylthio)methylene)-2-(trifluoromethyl)phenylacetonitrile
- α-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
- (2Z)-3-amino-3-[(4-aminophenyl)sulfanyl]-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
- MEK Inhibitor VII
- (Z)-3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile SL 327
- SL 327
alpha-[Amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)benzeneacetonitrile
- Mek-1/Mek-2 Inhibitor
- SL327;SL-327;MEK-1/MEK-2 INHIBITOR
- (Z)-3-amino-3-(4-aminophenyl)sulfanyl-2-[2-(trifluoromethyl)phenyl]prop-2-enenitrile
- SL 327; SL-327
- CS-1890
- Benzeneacetonitrile, α-[amino[(4-aminophenyl)thio]methylene]-2-(trifluoromethyl)-
- 3-amino-3-(4-aminophenylthio)-2-(2-(trifluoromethyl)phenyl)acrylonitrile
- SL 327 USP/EP/BP
- MEK Inhibitor VII SL327 SL-327
- Mitogen-activated protein kinase kinase,SL327,MEK,inhibit,Inhibitor,MAPKK,MAP2K
- SL 327, MEK inhibitor
- SL327, 10 mM in DMSO
- 305350-87-2
- C16H12F3O3S
- Kinase/Phosphatase Biology
- Mitogen-Activated Protein Kinase Kinase (MAPKK)
- Serine/Threonine Kinase Inhibitors
- Cell Signaling and Neuroscience
- BioChemical
- Cell Biology
- Inhibitors
- Protein Kinase
- Signalling
- MAPK
