Hexan-1,6-diol Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSE KRISTALLE.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft m?glich.
CHEMISCHE GEFAHREN
Reagiert sehr heftig mit Oxidationsmitteln.
ARBEITSPLATZGRENZWERTE
TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation des Aerosols.
INHALATIONSGEFAHREN
Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitssch?dliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Augen.
LECKAGE
Verschüttetes Material in Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste mit viel Wasser wegspülen.
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
Chemische Eigenschaften
white waxy flakes
Verwenden
1,6-Hexanediol is used in polymer synthesis such as polyester, polyurethane and nylon. It is used as an intermediate to adhesives, acrylics and dyestuffs. Further, it is employed in gasoline refining and pharmaceutical production.
Vorbereitung Methode
1,6-Hexanediol is produced industrially by the catalytic hydrogenation of adipic acid or of its esters. Mixtures of dicarboxylic acids and hydroxycarboxylic acids with C6 components formed in other processes (e.g., in cyclohexane oxidation) are also used. Esterifification of "distillation heavies" with lower alcohols is often carried out before hydrogenation. The acids are hydrogenated continuously at 170-240 ℃ and at 15.0-30.0 MPa on a suitable catalyst either in a trickle-flflow (downflflow) or a bubble-flflow (upflflow) fifixed-bed reactor. The reactor temperature is controlled by circulating part of the reactor discharge. The hydrogen required for the hydrogenation is fed together with the recycle gas through the recycle gas compressor to the reactor. Side products of the synthesis are alcohols, ethers, diols, and esters. Pure 1,6-hexanediol is obtained by fractional distillation of the crude reactor discharge. For the hydrogenation of dicarboxylic acids, catalysts containing cobalt, copper, or manganese are suitable. For the hydrogenation of esters, catalysts such as copper chromite or copper with added zinc and barium are used as "full catalysts" or on inert carriers. Ruthenium, platinum, or palladium on inert supports can also be used. Gas-phase hydrogenation of esters of adipic or 6-hydroxyhexanoic acid can be carried out at 1-7 MPa. Both acids and esters also may be hydrogenated using suspended catalysts. Oligomeric esters of the product diol and adipic acid can also be hydrogenated.
Definition
ChEBI: A diol that is hexane substituted by hydroxy groups at positions 1 and 6.
Hazard
Toxic by ingestion.
l?uterung methode
Fractionally crystallise it from its melt or from water. Distil it in vacuo. [Beilstein 1 IV 2556.]
Einzelnachweise
[1] Yuji Itoh. “1,6-hexanediol rapidly immobilizes and condenses chromatin in living human cells.” ACS Applied Electronic Materials (2021).
Hexan-1,6-diol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
