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PENITREM A

PENITREM A Struktur
12627-35-9
CAS-Nr.
12627-35-9
Englisch Name:
PENITREM A
Synonyma:
PENITREM A;TREMORTIN A;JDUWHZOLEDOQSR-JKPSMKLGSA-N;Penitrem A Nsc354845;Penitrem A, blocker of KCa1.1;PENITREM A, PENICILLIUM PAXILLI;Penitrem A from Penicillium paxilli;penitrem A from penicillium palitans;7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14b...;2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
CBNumber:
CB4155421
Summenformel:
C37H44ClNO6
Molgewicht:
634.2
MOL-Datei:
12627-35-9.mol

PENITREM A Eigenschaften

Schmelzpunkt:
238°C
Dichte
1.0241 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
2-8°C
L?slichkeit
Soluble in DMSO (up to 6 mg/ml)
Aggregatzustand
White solid.
pka
13.22±0.70(Predicted)
Farbe
Amorphous solid
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T+,T
R-S?tze: 26/27/28
S-S?tze: 36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS-Nr. RY7535000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29349990
Toxizit?t LD50 orl-mus: 10 mg/kg 41KEAL -,108,78
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H300 Lebensgefahr bei Verschlucken. Akute Toxizit?t oral Kategorie 2 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit

PENITREM A Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R26/27/28:Sehr giftig beim Einatmen, Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).

Chemische Eigenschaften

Solid

Occurrence

A series of closely related metabolites of Penicillium crustosum has recently been isolated and the components separated chromatographically. Penitrem A forms colourless crystals from EtOH.

Verwenden

Penitrem A is a tremorgenic mycotoxin isolated from Penicillium species. Penitrem A is a selective blocker of high-conductance Ca2+-activated potassium channels.

Sicherheitsprofil

Poison by ingestion and intraperitoneal routes. An experimental teratogen. When heated to decomposition it emits very toxic fumes of Clí and NOx.

PENITREM A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PENITREM A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 96)Lieferanten
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J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76
Sigma-Aldrich 021-61415566 800-8193336
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Alta Scientific Co., Ltd. 022-6537-8550 15522853686
 sales@altasci.com.cn China 4511 55
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58

12627-35-9()Verwandte Suche:

  • TREMORTIN A
  • Penitrem A from Penicillium paxilli
  • PENITREM A
  • PENITREM A, PENICILLIUM PAXILLI
  • penitrem A from penicillium palitans
  • Penitrem A Nsc354845
  • JDUWHZOLEDOQSR-JKPSMKLGSA-N
  • 2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14bS,14cR,16aS)-12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-7,8-(epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol
  • 7,8-(Epoxymethano)-2H,6H-cyclobuta[5,6]benz[1,2-e]oxireno[4',4'a]-1-benzopyrano[5',6':6,7]indeno[1,2-b]indole-3,4b,7d(5H,7H)-triol, 12-chloro-3,3a,6a,8,9,9a,10,11,14,14b,14c,15,16,16a-tetradecahydro-14b,14c,17,17-tetramethyl-10-methylene-2-(1-methylethenyl)-, (2R,3S,3aR,4aS,4bS,6aR,7S,7dR,8R,9aR,14b...
  • Penitrem A, blocker of KCa1.1
  • 12627-35-9
  • C37H44ClNO6
  • BioChemical
  • Cell Signaling and Neuroscience
  • Cell Biology
  • Monovalent Ion Channels
  • Potassium Channel Modulators
  • Ion Channels
  • Voltage-gated Ion Channels
  • antibiotic
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