2-CHLORO-4-PHENYLQUINAZOLINE
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- CAS-Nr.
- 29874-83-7
- Englisch Name:
- 2-CHLORO-4-PHENYLQUINAZOLINE
- Synonyma:
- quinazoL;oro-4-phenyL;2-CHLORO-4-PHENYLQUIZOLINE;2-CHLORO-4-PHENYLQUINAZOLIN;2-Chloro-4-phenylq inazollne;2-CHLORO-4-PHENYLQUINAZOLINE;Quinazoline,2-chloro-4-phenyl-;2-CHLORO-4-PHENYLQUINAZOLINE ISO 9001：2015 REACH
- CBNumber:
- CB41490329
- Summenformel:
- C14H9ClN2
- Molgewicht:
- 240.69
- MOL-Datei:
- 29874-83-7.mol
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2-CHLORO-4-PHENYLQUINAZOLINE Eigenschaften
- Schmelzpunkt:
- 113.0 to 117.0 °C
- Siedepunkt:
- 347.4±30.0 °C(Predicted)
- Dichte
- 1.285±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Aggregatzustand
- powder to crystal
- pka
- 0.24±0.30(Predicted)
- Farbe
- White to Orange to Green
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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2-CHLORO-4-PHENYLQUINAZOLINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.
Synthese
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).
2-CHLORO-4-PHENYLQUINAZOLINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2-CHLORO-4-PHENYLQUINAZOLINE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 184)Lieferanten
29874-83-7()Verwandte Suche:
- 2-CHLORO-4-PHENYLQUIZOLINE
- Quinazoline,2-chloro-4-phenyl-
- 2-CHLORO-4-PHENYLQUINAZOLIN
- oro-4-phenyL
- quinazoL
- 2-CHLORO-4-PHENYLQUINAZOLINE ISO 9001：2015 REACH
- 2-CHLORO-4-PHENYLQUINAZOLINE
- 2-Chloro-4-phenylq inazollne
- 29874-83-7
- quinazoline
