Lercanidipine
|
|
|
- CAS-Nr.
- 100427-26-7
- Englisch Name:
- Lercanidipine
- Synonyma:
- Rec-15-2375;Masnidipine;LERCANIDIPINE;Lercanadipine;Lercanidipine 13C-d3;LercanidipineC36H41N306;Lercanidipine USP/EP/BP;LERCANIDIPINE(FORR&DONLY);methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;LercanidipineQ: What is
Lercanidipine Q: What is the CAS Number of
Lercanidipine Q: What is the storage condition of
Lercanidipine
- CBNumber:
- CB4133658
- Summenformel:
- C36H41N3O6
- Molgewicht:
- 611.73
- MOL-Datei:
- 100427-26-7.mol
|
Lercanidipine Eigenschaften
- Schmelzpunkt:
- 118-120°C
- Siedepunkt:
- 712.5±60.0 °C(Predicted)
- Dichte
- 1.177±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- L?slichkeit
- Soluble in DMSO
- Aggregatzustand
- Powder
- pka
- 8.66±0.50(Predicted)
- Farbe
- Light yellow to yellow
- CAS Datenbank
- 100427-26-7(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Lercanidipine Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Lerdip was launched in the Netherlands for hypertension. It is prepared in
four steps, the last of which is a Hantsch reaction of 1-[(3,3-diphenyl)-N-methylpropylamino]-
2-methyl-2-propyl-2-(3-nitrobenzylidene)acetoacetate with methyl
3-aminocrotonate. This compound was designed to be very lipophilic which imparts
the drug with a gradual onset and a long duration of action as a result of prolonged
exposure to receptors by partitioning into membranes. It is an antagonist of L-type
calcium channels with no activity in smooth muscle cells, is tissue selective, lacks any
myocardial contractility impairment, has no neuroendocrine activation, and has
negligible affinity for neurotransmitter receptors such as α
1- and α
2-adrenergic
receptors. While sold as a racemate, the calcium channel activity is found in the (S)-
isomer with the (R)-isomer being 2-orders of magnitude less active. It has an
increased cardiac contractility index which is much more than Nitrendipine or
nifedipine. The good selectivity causes a reduction in blood pressure with no negative
inotropic effects.
Verwenden
Antihypertensive compound; calcium channel blocker.
Lercanidipine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Lercanidipine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 158)Lieferanten
100427-26-7()Verwandte Suche:
- LERCANIDIPINE
- 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITTROPHENYL)-3,5-PYRIDINEDICARBOXYLIC ACID 2-[(3,3-DIPHENYLPROPYL)METHYLAMINO]-1,1-DIMETHYLETHYL METHYL ESTER
- methyl [2-(3,3-diphenylpropyl-methyl-amino)-1,1-dimethyl-ethyl] 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- LercanidipineC36H41N306
- 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl]5-methyl ester
- 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3,5-pyridinedicarboxylic acid 3-methyl 5-[1,1-dimethyl-2-[methyl(3,3-diphenylpropyl)amino]ethyl] ester
- Masnidipine
- Rec-15-2375
- LERCANIDIPINE(FORR&DONLY)
- Lercanidipine 13C-d3
- 5-O-[1-[3,3-diphenylpropyl(methyl)amino]-2-methylpropan-2-yl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
- 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3-[2-[(3,3-diphenylpropyl)methylamino]-1,1-dimethylethyl] 5-methyl ester
- Lercanadipine
- Lercanidipine USP/EP/BP
- LercanidipineQ: What is
Lercanidipine Q: What is the CAS Number of
Lercanidipine Q: What is the storage condition of
Lercanidipine
- 100427-26-7
- 100472-26-7
- 132566-11-6
- C36H41N3O6
- Inhibitors
- inhibitor
