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marcfortine A

marcfortine A Struktur
75731-43-0
CAS-Nr.
75731-43-0
Englisch Name:
marcfortine A
Synonyma:
UK 111866;marcfortine A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-
CBNumber:
CB41323193
Summenformel:
C28H35N3O4
Molgewicht:
477.602
MOL-Datei:
75731-43-0.mol

marcfortine A Eigenschaften

Schmelzpunkt:
245 °C
Siedepunkt:
660.6±55.0 °C(Predicted)
Dichte
1.33±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
Methanol: soluble
Aggregatzustand
A solid
pka
12.05±0.60(Predicted)

Sicherheit

marcfortine A Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

Verwenden

Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.

marcfortine A Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

marcfortine A Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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75731-43-0()Verwandte Suche:

  • marcfortine A
  • UK 111866
  • Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-
  • 75731-43-0
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