Ertapenem Disodium
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- CAS-Nr.
- 153832-38-3
- Englisch Name:
- Ertapenem Disodium
- Synonyma:
- ERTAPENEM NA;Ertapenen Sodium;Ertapenem disodium;Ertapenam disodium;Ertapenem Disodium 90%;ErtapeneM SodiuM(crude);Ertapenem (sodium salt);Ertapenem Disodium (85%);Ertapenem Disodium USP/EP/BP;1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
- CBNumber:
- CB41261369
- Summenformel:
- C22H26N3NaO7S
- Molgewicht:
- 499.51
- MOL-Datei:
- 153832-38-3.mol
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Ertapenem Disodium Eigenschaften
- Schmelzpunkt:
- 230-234°C (dec.)
- storage temp.
- Sealed in dry,2-8°C
- L?slichkeit
- Methanol (Slightly), Water (Slightly)
- Aggregatzustand
- Solid
- Farbe
- White to Off-White
- Stabilit?t:
- Unstable at room temperature!
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P332+P313 |
Bei Hautreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P362 |
Kontaminierte Kleidung ausziehen und vor erneutem Tragen waschen. |
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Ertapenem Disodium Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ertapenem sodium was introduced in the US as a once daily intravenous or
intramuscular injection for the treatment of adult patients with moderate to severe bacterial
infections. This new I-β-methyl carbapenem can be assembled from commercially
available 4-nitrobenzyl protected β-methyl carbapenem enolphosphate and the appropriate
thiol derivative. The last intermediate can be synthesized from a suitably N-protected 4-
hydroxy proline derivative in a one pot operation involving bis activation of the carboxy and
hydroxy groups, reaction with sodium sulfide yielding the corresponding thiolactone,
aminolysis with 2-aminobenzoic acid and Kdeprotection. This bacterial cell wall synthesis
inhibitor has broad spectrum antimicrobial activity including common Gram-positive and
Gram-negative aerobic pathogens and restricted activity against nosocomial pathogens
such as Pseudomonas aeruginosa, Acinetobacfer species, methicillin-resistant
staphylococci and enterococci. Ertapenem is resistant to a broad and extended spectrum
of β-lactamases (excluding metallo-beta-lactamase) and is also more resistant than
imipenem to human renal dehydroxypeptidase-I-inactivation (DHP-I). In drug-resistant
strains of P. aeruginosa, resistance to ertapenem and imipenem was common but almost
all strains remain susceptible to at least one antipseudomal agent. In phase III studies,
ertapenem showed efficacy in the treatment of obstetric and gyneacological infections,
skin and soft tissues infections, community-acquired pneumonia, urinary tract infections
and in intra abdominal infections. Ertapenem has improved pharmacokinetics over
currently available carbapenems and cephalosporins with an extended serum half-life of 4h. The overall safety and tolerability profile of ertapenem was comparable to that seen with
comparator antibacterials.
Chemische Eigenschaften
Pale Yellow Solid
Verwenden
Group 1 carbapenem antibiotic. An antibacterial.
Ertapenem Disodium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Ertapenem Disodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 119)Lieferanten
- 1-Azabicyclo(3.2.0)hept-2-ene-2-carboxylic acid
- ErtapeneM SodiuM(crude)
- disodium (4R,5R,6S)-3-[(3S,5S)-5-[(3-carboxylatophenyl)carbamoyl]pyrro lidin-3-yl]sulfanyl-6-(1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2 .0]hept-2-ene-2-carboxylate
- Ertapenem disodium
- Ertapenem Disodium (85%)
- Ertapenem (sodium salt)
- Ertapenam disodium
- Ertapenem Disodium 90%
- ERTAPENEM NA
- Ertapenem Disodium USP/EP/BP
- sodium (4R,5S,6S)-3-(((3S,5S)-5-((3-carboxylatophenyl)carbamoyl)pyrrolidin-3-yl)thio)-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate
- sodium 3-((2S,4S)-4-(((4R,5S,6S)-2-carboxy-6-((R)-1-hydroxyethyl)-4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-en-3-yl)thio)pyrrolidine-2-carboxamido)benzoate
- 1-Azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, 3-[[(3S,5S)-5-[[(3-carboxyphenyl)amino]carbonyl]-3-pyrrolidinyl]thio]-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-, sodium salt (1:2), (4R,5S,6S)-
- Ertapenen Sodium
- 153832-38-3
- C22H25N3O7S2Na
- C22H23N3Na2O7S
- C22H23N3O7S2Na
- Aromatics
- Chiral Reagents
- Heterocycles
- Intermediates & Fine Chemicals
- Pharmaceuticals
- Sulfur & Selenium Compounds
- API
