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4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridon

3-Deazauridine Struktur
23205-42-7
CAS-Nr.
23205-42-7
Bezeichnung:
4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridon
Englisch Name:
3-Deazauridine
Synonyma:
NSC-126849;3-deazuridine;3-DEAZAURIDINE;3-DEAZAURIDINE CRYSTALLINE;3Deazauridine,3 Deazauridine;3-Deazauridine,anticancer antiviral;1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone;4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone;4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone;4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
CBNumber:
CB4125871
Summenformel:
C10H13NO6
Molgewicht:
243.21
MOL-Datei:
23205-42-7.mol

4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridon Eigenschaften

Schmelzpunkt:
233-235°C
Siedepunkt:
569.2±50.0 °C(Predicted)
Dichte
1.718±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
DMSO (Slightly), Methanol (Slightly), Water (Slightly)
Aggregatzustand
Solid
pka
4.50±1.00(Predicted)
Farbe
White to Pale Beige
InChI
InChI=1/C10H13NO6/c12-4-6-8(15)9(16)10(17-6)11-2-1-5(13)3-7(11)14/h1-3,6,8-10,12-13,15-16H,4H2/t6-,8-,9-,10-/s3
InChIKey
CBOKZNLSFMZJJA-FNMQVXAUNA-N
SMILES
[C@@H]1([C@H](O)[C@H](O)[C@@H](CO)O1)N1C=CC(O)=CC1=O |&1:0,1,3,5,r|
LogP
-1.693 (est)

Sicherheit

RTECS-Nr. UV1148000

4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridon Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

3-Deazauridine is a structural analog of uridine that inhibits the biosynthesis of Cytidine-5'-Triphosphate by competitive inhibition of Cytidine Triphosphate synthetase, which is considered to be the primary mode of action of this nucleoside analog. This compound has been shown to possess in vitro activity against leukemia L1210 tumor cells, Ehrlich ascites tumor cells, Escherichia coli, and Streptococcus faecium. Despite a paucity of clinical attention given to this drug as a single agent, it has generated much enthusiasm as a biological response modulator because of its synergistic effect with several antitumor agents, including Cytosine Arabinoside, 5-aza-2'-deoxycytidine, 5-azacytidine, thymidine and D-galactosamine. However, only the cytosine arabinoside/3-Deazauridine combination has been explored clinically[1-2].

Verwenden

Antimetabolite antiviral dosing regimen for hepatitis C virus or flaviviridae therapy.

4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 76)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
PANNACEAN(HENAN)MEDICINE SCIENCE TECHNOLOGIES LTD
0371-55159968 18137130222
 haifeng.zhang@pannacean.com China 527 58
Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10310 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32024 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30241 58
BOC Sciences 		16314854226; +16314854226
 inquiry@bocsci.com United States 19741 58
NewCan Biotech Limited 		+86-0571-86912261 +8613735419629
 sales@newcanbio.com China 9980 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38463 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Wuhan Fortuna Chemical Co.,Ltd 		+8618007136271
 hk@fortunachem.com China 5998 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58

23205-42-7(4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridon)Verwandte Suche:

  • 4-HYDROXY-1-BETA-D-RIBOFURANOSYL-2[1H]PYRIDONE
  • 3-DEAZAURIDINE
  • 3-deazuridine
  • 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinon
  • 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridinone
  • 4-hydroxy-1-beta-d-ribofuranosyl-2(1h)-pyridon
  • 3-DEAZAURIDINE CRYSTALLINE
  • 1-β-D-Ribofuranosyl-4-hydroxy-2-pyridone
  • 4-Hydroxy-1-(β-D-ribofuranosyl)-2-pyridone
  • 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)pyridone
  • 4-Hydroxy-1-(β-D-ribofuranosyl)-1,2-dihydropyridin-2-one
  • 4-Hydroxy-1-β-D-ribofuranosyl-2(1H)-pyridinone
  • NSC-126849
  • 4-Hydroxy-1-(beta-D-ribofuranosyl)-2-pyridone
  • 1-[(2R,3R,4S,5R)-3,4-DIHYDROXY-5-(HYDROXYMETHYL)OXOLAN-2-YL]-2-HYDROXYPYRIDIN-4-ONE
  • 2(1H)-Pyridinone, 4-hydroxy-1-β-D-ribofuranosyl-
  • 3-Deazauridine, 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, 3-DAU, NSC 126849
  • 2(1H)-Pyridinone,4-hydroxy-1-b-D-ribofuranosyl-
  • 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-hydroxypyridin-2(1H)-one
  • 3-Deazauridine,4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, synthetase inhibitor, anticancer drug, NSC126849, 3D2U
  • 4-Hydroxy-1-beta-D-ribofuranosyl-2(1H)-pyridinone, NSC126849
  • 3Deazauridine,3 Deazauridine
  • 3-Deazauridine,anticancer antiviral
  • 23205-42-7
  • 232005-42-7
  • 20235-47-2
  • C10H13NO6
  • Bases & Related Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
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