Ravuconazole
|
|
|
- CAS-Nr.
- 182760-06-1
- Englisch Name:
- Ravuconazole
- Synonyma:
- Rcz;Er-30346;Aids057176;Bms-207147;The health;Bms-207,147;Aids-057176;Rafconazole;Ravuconazole;Levaconazole
- CBNumber:
- CB41257944
- Summenformel:
- C22H17F2N5OS
- Molgewicht:
- 437.47
- MOL-Datei:
- 182760-06-1.mol
|
Ravuconazole Eigenschaften
- Schmelzpunkt:
- 64-66°C
- alpha
- D24 -29.1° (c = 1.03 in methanol)
- Siedepunkt:
- 674.9±65.0 °C(Predicted)
- Dichte
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- L?slichkeit
- DMF: 25 mg/ml; DMF:PBS (pH 7.2) (1:4): 0.25 mg/ml; DMSO: 20 mg/ml; Ethanol: 5 mg/ml
- Aggregatzustand
- A crystalline solid
- pka
- 11.62±0.29(Predicted)
- Farbe
- Off-white to yellow
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Ravuconazole Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Ravuconazole is an orally available triazole fungicide that potently inhibits the growth of a wide range of fungi (MICs range from 25 to 780 ng/ml). Like other azoles, ravuconazole inhibits cytochrome P450 (CYP) isoforms that are involved in ergosterol biosynthesis, interfering with the generation of the fungal and protozoan cell membranes. Ravuconazole specifically inhibits sterol 14α-demethylase (CYP51). As this enzyme is also important in the development of trypanosomes, ravuconazole is effective against
T. cruzi infections in animal models of Chagas disease.
Chemische Eigenschaften
Off-White Solid
Verwenden
Ergosterol biosynthesis inhibitor. Antifungal.
Ravuconazole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)butanethioaMide
(αS,βR)-β-(2,4-Difluorophenyl)-β-hydroxy-α-Methyl-1H-1,2,4-triazole-1-butanenitrile
2-Chloro-2',4'-difluoroacetophenone
4-(2-Bromoacetyl)benzonitrile
(2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-2-Methyl-4-(1H-1,2,4-triazol-1-yl)thiobutyraMide
3-chloro-2-(2,4-difluorophenyl)-2-(trimethylsilanyloxy)propionaldehyde
(S)-3-chloro-2-(2,4-difluorophenyl)-2-((trimethylsilyl)oxy)propanenitrile
4'-Cyanacetophenon
Downstream Produkte
Ravuconazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 101)Lieferanten
- Aids057176
- 4-[2-[(2R,3R)-3-(2,4-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)b utan-2-yl]-1,3-thiazol-4-yl]benzonitrile
- Aids-057176
- Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluro-phenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-
- Bms-207,147
- Bms-207147
- Er-30346
- Rcz
- Benzonitrile, 4-[2-[(1R,2R)-2-(2,4-difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]-
- Ravuconazole, BMS-207147
- [R-(R*,R*)]-4-{2-[2-(2,4-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)-propyl]-4-thiazolyl}-benzonitrile
- BMS-207147/Ravuconazole
- 4-(2-((2R,3R)-3-(2,4-Difluorophenyl)-3-hydroxy-4-(1H-1,2,4-triazol-1-yl)butan-2-yl)thiazol-4-yl)benzonitrile
- The health
- Ravuconazole
- inhibit,ER30346,BMS207147,Ravuconazole,BMS 207147,Fungal,ER 30346,Inhibitor
- Ravuconazole Impurity 1
- Levaconazole
- Rafconazole
- 182760-06-1
- C22H17F2N5OS
- Aromatics
- Chiral Reagents
- Heterocycles
- Inhibitors
- Intermediates & Fine Chemicals
- Pharmaceuticals
