ACPA
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- CAS-Nr.
- 229021-64-1
- Englisch Name:
- ACPA
- Synonyma:
- ACPA;PRTN3;ARACHIDONYLCYCLOPROPYLAMIDE;ACPA (in Tocrisolve(TM) 100);ARACHIDONOYL CYCLOPROPYLAMIDE;Arachidonylcyclopropylamide (ACPA);Recombinant Human PRTN3 Protein, His Tag;N-(CYCLOPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE;Monoclonal Anti-PRTN3 antibody produced in mouse;α-Amino-3-carboxy-5-methylisoxazole-4-propionic acid
- CBNumber:
- CB4124177
- Summenformel:
- C23H37NO
- Molgewicht:
- 343.55
- MOL-Datei:
- 229021-64-1.mol
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ACPA Eigenschaften
- Siedepunkt:
- 502.4±50.0 °C(Predicted)
- Dichte
- 0.93±0.1 g/cm3(Predicted)
- RTECS-Nr.
- JX3841600
- storage temp.
- −20°C
- L?slichkeit
- DMSO: soluble
- pka
- 16.13±0.20(Predicted)
- Aggregatzustand
- Pale yellow oil.
- Farbe
- Colorless to light yellow
- Sensitive
- Air Sensitive
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
 
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P233 |
Beh?lter dicht verschlossen halten. |
| P240 |
Beh?lter und zu befüllende Anlage erden. |
| P241 |
Explosionsgeschützte [elektrische/Lüftungs-/ Beleuchtungs-/...] Ger?te verwenden. |
| P242 |
Nur funkenfreies Werkzeug verwenden. |
| P243 |
Ma?nahmen gegen elektrostatische Entladungen treffen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
| P337+P313 |
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
| P370+P378 |
Bei Brand: zum L?schen verwenden. |
| P403+P235 |
An einem gut belüfteten Ort aufbewahren. Kühl halten. |
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ACPA Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Arachidonoyl cyclopropylamide (ACPA) is a potent and selective cannabinoid (CB) receptor 1 agonist with K
i values of 2.2 and 715 nM for CB
1 and CB
2 receptors, respectively. In whole animal experiments, ACPA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide (AEA; ), in spite of its higher affinity for the CB
1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in whole animal experiments.
Verwenden
A synthetic agonist of the cannabinoid receptor 1 (CB1R). ACPA is considered to be a selective cannabinoid agonist as it binds primarily to the CB1R and has low affinity to the cannabinoid receptor 2
(CB2R).
Biologische Aktivit?t
Potent and selective CB 1 agonist (K i = 2.2 nM). Displays 325-fold selectivity over CB 2 receptors. Active in vivo . Also available in water soluble emulsion (N-(Cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide ).
Enzyminhibitor
This highly selective, synthetic CB1 receptor agonist (FW = 343.55 g/mol; CAS 229021-64-1), also known as arachidonylcyclopropylamide and N(cyclopropyl)-5Z,8Z,11Z,14Z-eicosatetraenamide, targets CB1 cannabinoid receptor agonist (Ki = 2.2 nM) with >325-fold selectivity over CB2 receptors. Two subtypes of the cannabinoid receptor (CB1 and CB2) are expressed in mammalian tissues. Although selective antagonists are available for each of the subtypes, most of the available cannabinoid agonists bind to both CB1 and CB2 with similar affinities. ACPA possesses the characteristics of CB1 receptor agonists, inhibiting forskolininduced cAMP accumulation in Chinese hamster ovary cells expressing the human CB1 receptor. It also increases the binding of [35S]GTPgS to cerebellar membranes and inhibits electrically evoked contractions of the mouse vas deferens. See also ACEA
ACPA Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
ACPA Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 61)Lieferanten
- ACPA
- ARACHIDONYLCYCLOPROPYLAMIDE
- ARACHIDONOYL CYCLOPROPYLAMIDE
- N-(CYCLOPROPYL)-5Z,8Z,11Z,14Z-EICOSATETRAENAMIDE
- α-Amino-3-carboxy-5-methyl-4-isoxazolepropionic acid
- α-Amino-3-carboxy-5-methylisoxazole-4-propionic acid
- ACPA (in Tocrisolve(TM) 100)
- (5Z,8Z,11Z,14Z)-N-Cyclopropyl-5,8,11,14-eicosatetraenaMide
- Monoclonal Anti-PRTN3 antibody produced in mouse
- PRTN3
- Arachidonylcyclopropylamide (ACPA)
- Recombinant Human PRTN3 Protein, His Tag
- 5,8,11,14-Eicosatetraenamide, N-cyclopropyl-, (5Z,8Z,11Z,14Z)-
- 229021-64-1
- C23H37NO
- Cannabinoid receptor
- Cannabinoid
- Agonist
- Fatty Acid Derivatives & Lipids
- Glycerols
- Intermediates & Fine Chemicals
- Pharmaceuticals
