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Forodesine

Forodesine Struktur
209799-67-7
CAS-Nr.
209799-67-7
Englisch Name:
Forodesine
Synonyma:
Fodosine;Forodesine;Isopamphos;Immucillin-H;BCX-1777 freebase;FORODESINE FODOSINE;(1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride;(1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H;4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-;7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
CBNumber:
CB41120376
Summenformel:
C11H14N4O4
Molgewicht:
266.25
MOL-Datei:
209799-67-7.mol

Forodesine Eigenschaften

Siedepunkt:
613.5±65.0 °C(Predicted)
Dichte
2.01
storage temp. 
Hygroscopic, Refrigerator, under inert atmosphere
L?slichkeit
PBS (pH 7.2): 5 mg/ml
Aggregatzustand
A crystalline solid
pka
13.88±0.70(Predicted)
Farbe
Light brown to gray

Sicherheit

Forodesine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Forodesine is a purine nucleoside analog and purine nucleoside phosphorylase (PNP) inhibitor (IC50s = 1.19, 0.48, 1.24, 0.66, and 1.57 nM for human, mouse, rat, monkey, and dog PNP, respectively). It inhibits phytohemagglutinin A-, mixed lymphocyte reaction-, or IL-2-induced proliferation of isolated human peripheral blood lymphocytes (PBLs; IC50s = <0.1-0.38 μM) in the presence, but not absence, of 2’-deoxyguanosine (dGuo). Forodesine inhibits proliferation of CEM-SS T cell acute lymphoblastic leukemia (T-ALL) cells. In vivo, forodesine (10 mg/kg) prolongs survival in the hu-PBL-SCID mouse model of xenogeneic graft versus host disease (GVHD).

Verwenden

Treatment of T-Cell malignancies such as acute lymphoblastic leukemia (ALL) and cutaneous T-cell lymphoma (CTCL) Fodosine.

Forodesine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Forodesine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 49)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Hefei Hirisun Pharmatech Co., Ltd
+8615056975894
shawn@hirisunpharm.com CHINA 9911 58
NewCan Biotech Limited
+86-0571-86912261 +8613735419629
sales@newcanbio.com China 9981 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418684 +8618949823763
sales@tnjchem.com China 25356 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Suzhou ARTK Medchem Co., Ltd.
+86-512-68323658 +86-18168183658
sales1@artkmedchem.com China 39004 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
NCE Biomedical Co.,Ltd. 4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988
China 1493 55

209799-67-7()Verwandte Suche:


  • 4H-Pyrrolo3,2-dpyrimidin-4-one, 7-(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl-1,5-dihydro-
  • Forodesine
  • 7-[(2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)-2-pyrrolidinyl]-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
  • Fodosine
  • Immucillin-H
  • (1S)-1-(9-deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-iMino-D-ribitol, iMMucillin H
  • FORODESINE FODOSINE
  • 4H-Pyrrolo[3,2-d]pyriMidin-4-one,7-[(2S,3S,4R,5R)-3,4-dihydroxy-5-(hydroxyMethyl)-2-pyrrolidinyl]-3,5-dihydro-
  • BCX-1777 freebase
  • Isopamphos
  • (1S)-1-(9-Deazahypoxanthin-9-yl)-1,4-dideoxy-1,4-imino-D-ribitol-hydrochloride
  • 7-((2S,3S,4R,5R)-3,4-Dihydroxy-5-(hydroxymethyl)pyrrolidin-2-yl)-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one
  • 209799-67-7
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