BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.
P337+P313
Bei anhaltender Augenreizung: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren. S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Verwenden
1,8-Dichloroanthraquinone is a reagent in the preparation of anthraquinones, which has antitumor activities. It is used as primary and secondary intermediate.
Sicherheitsprofil
An eye irritant. When
heated to decomposition it emits toxic
fumes of Cl-.
Synthese
1,8-Dichloroanthraquinone is prepared by the reaction of 1-chloroanthracene-9,10-dione and 2-chloroanthracene-9,10-dione. The steps are as follows: 80 L of the mother liquors obtained according to Example 1a and 40 L of the mother liquors obtained according to Example 1b are combined in a 250 L enamel kettle and heated to 100℃. 12 L of a 10% strength aqueous sodium chlorate solution are fed in at a uniform rate at this temperature in the course of 4 hours, while stirring at 30 - 40 revolutions per minute with an anchor stitter. The mixture is stirred for a further 2 hours at 100℃. and filtered at 80℃. through a filter press, the material on the filter is washed with hot water until the filtrate gives a neutral reaction and the filter cake is dried. 1,8-dichloroanthraquinone are obtained.
1,8-Dichloranthrachinon Upstream-Materialien And Downstream Produkte