Rizatriptan benzoate
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- CAS-Nr.
- 145202-66-0
- Englisch Name:
- Rizatriptan benzoate
- Synonyma:
- MAXALT;MK-462;MK-0462;Rizatrimptan;MK-462 Benzoate;Rizatriptan API;Rizatriptan Benzoat;RIZATRIPTAN BENZOATE;Rizatriptani benzoas;Rizatrimptan Benzoate
- CBNumber:
- CB4100441
- Summenformel:
- C22H25N5O2
- Molgewicht:
- 391.48
- MOL-Datei:
- 145202-66-0.mol
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Rizatriptan benzoate Eigenschaften
- Schmelzpunkt:
- 178-180°C
- storage temp.
- 2-8°C
- L?slichkeit
- H2O: ≥5mg/mL
- Aggregatzustand
- powder
- Farbe
- white to beige
- Merck
- 14,8241
- InChIKey
- JPRXYLQNJJVCMZ-UHFFFAOYSA-N
- CAS Datenbank
- 145202-66-0(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
61 |
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| WGK Germany |
3 |
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| HS Code |
2933995500 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H360 |
Kann die Fruchtbarkeit beeintr?chtigen oder das Kind im Mutterleib sch?digen. |
Fertility (Fruchtbarkeit) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
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| Sicherheit |
| P201 |
Vor Gebrauch besondere Anweisungen einholen. |
| P308+P313 |
BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen. |
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Rizatriptan benzoate Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Rizatriptan was launched for the first time as Maxalt in Mexico for the
acute treatment of migraine headaches with or without aura in adults. It is the
third in a new generation of triptan migraine drugs to challenge the firstgeneration
product Sumatriptan from Glaxo Wellcome, after Zolmitriptan
(Zeneca) and Naratriptan (Glaxo Wellcome).
It can be synthetically obtained by two related routes having respectively 3 and 4
steps, both starting from 1 -(4-aminobenzyl)-l,2,4-triazole. Rizatriptan is a full 5-HT1D/1B receptor agonist retaining a significant affinity at 5-HT1A sites (pIC50
= 6.4), with a low affinity for nond-HT sites. It shows craniovascufar selectivity
for human isolated middle meningeal over coronary arteries ; its effect on
coronary artery constriction is significantly less than that for Sumatriptan.
Rizatriptan inhibits the release of neuropeptides that cause swelling of cranial
blood vessels. Rizatriptan has a good oral bioavailability (64% and 47% in rats
and dogs respectively). and a rapid onset of action : the headache relief in
human occurs within 30 to 45 minutes of taking 20 mg. It also relieved nausea
and hypersensitivity to noise (phonophobia) and light (photophobia) that are
often symptoms accompanying a migraine attack. Among at least 6 metabolites
identified in humans after a single oral dose (60 mg), the major urinary
metabolite was the corresponding indole-3-acetic acid. Maxalt is available as a
novel oral formulation of rapidly dissolving tablets or wafers that does not require
liquid for ingestion.
Chemische Eigenschaften
Off-White Solid
Verwenden
Rizatriptan Benzoate is a selective serotonin 5-HTID receptor agonist and used to treat migraine (1,2,3). It is structurally derived from tryptamine.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Rizatriptan benzoate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Rizatriptan benzoate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 465)Lieferanten
145202-66-0()Verwandte Suche:
- RIZATRIPTAN BENZOATE
- N,N-DIMETHYL-5-(1H-1,2,4-TRIAZOL-1-YLMETHYL)-1H-INDOLE-3-ETHANAMINE, BENZOATE
- n,n-dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1h-indol-3-yl]ethylamine benzoate
- Rizatrimptan Benzoate
- Rizatrimptan
- Rizatriptan monobenzoate
- N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-
- Acid Bixente triptans
- MK-0462
- MK-462
- Rizatriptan benzoate,MaxaLt
- Rizatriptan Benzoate (200 mg)
- Rizatriptan benzoate API
- MK-462 Benzoate
- N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indole-3-ethanamine,benzoate (1:1)
- Rizatriptan benzoate
N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate
- N,N-Dimethyl-2-[5-(1,2,4-triazol-1-ylmethyl)-1H-indol-3-yl]ethylamine benzoate salt
- Rizatriptan benzoate salt
- Rizatriptan for system suitability
- 2-(5-((1H-1,2,4-triazol-1-yl)Methyl)-1H-indol-3-yl)-N,N-diMethylethanaMine benzoate
- Rizatriptan Benzoat
- Rizatriptan (as benzoate)
- RIZATRIPTANE BENZOATE
- Rizatriptan for system suitability CRS
- Rizatriptan Benzoate >
- Rizatriptan benzoate CRS
- Rizatriptan benzoate USP/EP/BP
- Rizatriptani benzoas
- Rizatriptan Benzoate (MK-462 Benzoate)
- Rizatriptan benzoateQ: What is
Rizatriptan benzoate Q: What is the CAS Number of
Rizatriptan benzoate Q: What is the storage condition of
Rizatriptan benzoate Q: What are the applications of
Rizatriptan benzoate
- Rizatriptan Benzoate (1604880)
- MAXALT
- 1H-Indole-3-ethanamine, N,N-dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-, benzoate (1:1)
- N,N-Dimethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1H-indol-3-ethanamine benzoate (1:1)
- 2-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1H-indol-3-yl)-N,N-dimethylethan-1-amine benzoate
- Rizatriptan API
- 3-[2-(Dimethylamino) ethyl]- 5- (1,2,4- triazol-1- ylmethyl) -indole benzoate, USP, IP
- 145202-66-0
- C15H19N5C7H6O2
- MK-462, Maxalt
- Heterocycles
- API
- Intermediates & Fine Chemicals
- Neurochemicals
- Pharmaceuticals
- Antimigraine
- Heterocyclic Compounds
- Rizatriptan
- Amines
