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PD 166793

PD 166793 Struktur
199850-67-4
CAS-Nr.
199850-67-4
Englisch Name:
PD 166793
Synonyma:
PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
CBNumber:
CB3840520
Summenformel:
C17H18BrNO4S
Molgewicht:
412.3
MOL-Datei:
199850-67-4.mol

PD 166793 Eigenschaften

Schmelzpunkt:
192-193℃
Dichte
1.457
storage temp. 
Sealed in dry,2-8°C
L?slichkeit
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
Aggregatzustand
A crystalline solid
Farbe
White to pink

Sicherheit

PD 166793 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.

Allgemeine Beschreibung

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Biologische Aktivit?t

Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

PD 166793 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

PD 166793 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 60)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30239 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22785 58
Nextpeptide Inc 		+86-0571-81612335 +8613336028439
 sales@nextpeptide.com China 19908 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490
 info@gihichemicals.com China 49978 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 94657 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69

199850-67-4()Verwandte Suche:

  • PD 166793
  • (S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid
  • N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
  • (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
  • MMP-2/MMP-3 Inhibitor
  • L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-
  • (2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci
  • PD 166793 USP/EP/BP
  • PD-166793-0000
  • (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
  • 199850-67-4
  • Angiogenesis and Metastasis
  • Protease inhibitor
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