N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethan-diamin, (Z)-2-butendioat (1:1) Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.

Beschreibung

Mepyramine is a first generation antihistamine that acts as an inverse agonist at the histamine H₁ receptor. It is reported to bind with high affinity to a G_q/11 protein-coupled form of the receptor and to promote a G protein-coupled inactive state of the H₁ receptor that interferes with the G_q/11-mediated signaling of the endogenously expressed receptor, as well as to reduce G protein availability for other non-related receptors associated with this signaling pathway. Mepyramine has been shown to inhibit histamine-induced inositol phosphate production with a log EC₅₀ value of -7.94.

Chemische Eigenschaften

solid

Verwenden

Pyrilamine maleate Selective inverse agonist for the H-1 histamine receptor. Pyrilamine Maleate is commonly utilized as a radioligand ([3H]Mepyramine) binding assay for the H1 receptor. And also used to exhibit blocking ability of KCNQ/M channels which is potentially related to an adverse effect seen in excess intake of antihistamines.

Allgemeine Beschreibung

White crystals or powder. Melting point 100-101°C. Bitter saline taste. An antihistaminic medicine.

Air & Water Reaktionen

Water soluble.

Reaktivit?t anzeigen

PYRILAMINE MALEATE is an acidic salt of an amine. Usually does not react as either oxidizing agents or reducing agents but such behavior is not impossible. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen may be generated in combination with strong reducing agents, such as hydrides.

Health Hazard

SYMPTOMS: Symptoms of exposure to PYRILAMINE MALEATE may include drowsiness, potentiation of the sedative effect of barbituates, fatigues, vertigo, incoordination, tremor, muscle weakness, dryness of the mouth and throat, tinnitus, pupillary dilation, blurred vision, urinary retention, impotence, epigastric and intestinal pain, anorexia, nausea, vomiting, diarrhea, excitation, euphoria, insomnia, nervousness, palpitation, tachycardia, hypotension, hypersensitivity reactions, respiratory depression, coma and delirium.

Brandgefahr

Flash point data for PYRILAMINE MALEATE are not available, however PYRILAMINE MALEATE is probably combustible.

Biologische Aktivit?t

Selective inverse agonist for the H 1 receptor. Inhibits histamine induced inositol phosphate (InsP) production (log EC50 = -7.94) and intracellular calcium mobilization. Sequesters G q/11 protein, reducing its availability for other receptors associated with the same signaling pathway.

Sicherheitsprofil

A human poison by ingestion. An experimental poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Questionable carcinogen with experimental tumorigenic data. Mutation data reported. An antihistamine. When heated to decomposition it emits toxic fumes of NOx.

N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethan-diamin, (Z)-2-butendioat (1:1) Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethan-diamin, (Z)-2-butendioat (1:1) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29886	58
Chongqing Chemdad Co., Ltd	+86-023-6139-8061 +86-86-13650506873	sales@chemdad.com	China	39894	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32024	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
AFINE CHEMICALS LIMITED	+86-0571-85134551	sales@afinechem.com	China	15361	58
Dayang Chem (Hangzhou) Co.,Ltd.	571-88938639 +8617705817739	info@dycnchem.com	China	52849	58
Henan Alfa Chemical Co., Ltd	+86-18339805032; +8618339805032	alfa4@alfachem.cn	China	13227	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38463	58
PT CHEM GROUP LIMITED		peter68@ptchemgroup.com	China	35425	58

59-33-6(N-((4-Methoxyphenyl)methyl)-N',N'-dimethyl-N-2-pyridinyl-1,2-ethan-diamin, (Z)-2-butendioat (1:1))Verwandte Suche:

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• MEPYRAMINE MALEATE
• MEPYRAMINE MALEATE SALT
• n-dimethylaminoethyl-n-p-methoxy-alpha-aminopyridinemaleate
• neo-anterganmeleate
• n-p-methoxybenzyl-n’-n’-dimethyl-n-alpha-pyridylethylenediaminemaleate
• paramal
• paraminylmaleate
• pymafed
• pyramaleate
• pyranilaminemaleate
• pyraninyl
• pyrilaminemaleatecrystalline
• renstamin
• stangenmaleate
• statominmaleate
• thylogenmaleate
• PYRILAMINE MALEATE METHANOL SOLUTION
• 2-((2-Dimethylaminoethyl)-(p-methoxybenzyl)amino)p(mepyraminemaleate)
• 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE
• PYRILAMINE MALEATE
• PYRILAMINE MALEATE SALT
• PYRANISAMINE MALEATE
• N-(P-METHOXYBENZYL)-N',N'-DIMETHYL-N-2-PYRIDYLETHYLENEDIAMINE MALEATE
• N-[4-METHOXY-PHENYL]METHYL-N',N'-DIMETHYL-N[2-PYRIDINYL]-1,2-ETHANEDIAMINE MALEATE SALT
• antihist
• diaminidemaleate
• minihist
• n-((4-methoxyphenyl)methyl)-n,n’-dimethyl-n-2-pyridinyl-2-ethanediamine
• n,n-dimethyl-n’-(4-methoxybenzyl)-n’-(2-pyridyl)ethylenediaminemaleate
• (z)-2-butenedioat
• 1,2-Ethanediamine,N-[(4-methoxyphenyl)methyl]-N’,N’-dimethyl-N-2-pyridinyl-,(Z)-2-butenedioate(1:1)
• 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)pyridinebimaleate
• 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridinmaleate(1:1)
• 2786r.p.maleate
• 2-ethanediamine,n-[(4-methoxyphenyl)methyl]-n’,n’-dimethyl-n-2-pyridinyl-(
• anisopyradamine
• anthisanmaleate
• 1,2-Ethanediamine, N-(4-methoxyphenyl)methyl-N,N-dimethyl-N-2-pyridinyl-, (2Z)-2-butenedioate (1:1)
• PYRILAMINEMALEATE,USP
• Histatex
• Pyrilaminmaleat
• 2-((2-(dimethylamino)ethyl)(p-methoxybenzyl)amino)-pyridin maleate
• 2-[(2-DIMETHYLAMINOETHYL)(P-METHOXYBENZYL)AMINO]PYRIDINE MALEATE USP
• PYRILAMINE MALEATE USP/NF
• Mepyramine maleate salt, N-(4-Methoxyphenyl)methyl-Nμ,Nμ-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine maleate salt
• Pyrilamine Maleate (200 mg)
• BiMaleate
• N-[(4-Methoxyphenyl)Methyl]-N',N'-diMethyl-N-2-pyridinyl- 1,2-ethanediaMine (2Z)-2-Butenedioate
• N1-[(4-Methoxyphenyl)Methyl]-N2,N2-diMethyl-N1-2-pyridinyl-1,2-ethanediaMine (2Z)-2-Butenedioate
• N1-(4-Methoxybenzyl)-N2,N2-diMethyl-N1-(pyridin-2-yl)ethane-1,2-diaMine fuMarate
• Mepyramine maleate CRS
• N-(4-Methoxybenzyl)-N′,N′-dimethyl-N-(pyridin-2- yl)ethane-1,2-diamine (Z)-butenedioate
• N1-(4-Methoxybenzyl)-N2,N2-dimethyl-N1-(pyridin-2-yl)ethane-1,2-diamine maleate
• PyrilamineMaleateSal
• N-(4-Methoxyphenyl)methyl-N',N'-dimethyl-N-(2-pyridinyl)-1,2-ethanediamine Maleate
• PYRILAMINE MALEATE USP/EP/BP
• Mepyramine maleateQ: What is Mepyramine maleate Q: What is the CAS Number of Mepyramine maleate Q: What is the storage condition of Mepyramine maleate Q: What are the applications of Mepyramine maleate
• Pyrilamine Maleate (1588004)