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PROSTAGLANDIN A1

PROSTAGLANDIN A1 Struktur
14152-28-4
CAS-Nr.
14152-28-4
Englisch Name:
PROSTAGLANDIN A1
Synonyma:
PGA1;Prostaglandin A;Prostagladin E1;C04685;pga(sub1);pga(sup1);Prostagladin A;PROSTAGLANDIN A1;PROSTAGLANDINS A1;prostaglandina(sup1)
CBNumber:
CB3666883
Summenformel:
C20H32O4
Molgewicht:
336.47
MOL-Datei:
14152-28-4.mol

PROSTAGLANDIN A1 Eigenschaften

Schmelzpunkt:
43°C
Siedepunkt:
392.93°C (rough estimate)
Dichte
1.0192 (rough estimate)
Brechungsindex
1.4434 (estimate)
storage temp. 
-20°C
L?slichkeit
acetone: 10 mg/mL, clear
Aggregatzustand
White solid.
pka
4.77±0.10(Predicted)
Farbe
Off-white
BRN 
2003401
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
S-S?tze: 22-24/25
WGK Germany  3
RTECS-Nr. GY5977900
8-10
HS Code  2937500000
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P201 Vor Gebrauch besondere Anweisungen einholen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

PROSTAGLANDIN A1 Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.

Beschreibung

Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen. It has been shown to cause renal vasodilation, increased urine sodium excretion, and lowered arterial pressure in hypertensive patients. It also has growth-inhibitory activity on tumor cells; the IC50 value for the inhibition of human ovarian cancer is 7.5 μM.

Verwenden

Prostaglandin A1 has been shown to inhibit human immunodeficiency virus type 1 (HIV-1) replication in various cell types. In addition, as a precursor to the anti-inflammatory prostaglandins, it activates pro-inflammatory PGD2 receptor CRTH2 initiating the anti-inflammatory response.

Allgemeine Beschreibung

Prostaglandin A1(PGA1) belongs to the class of cyclopentenone prostaglandin. PGA1 is generated by the dehydration of prostaglandin E1 (PGE1).

Enzyminhibitor

This eicosanoid (FWfree-acid = 336.47 g/mol; CAS 14152-28-4; Symbol: PGA1) induces apoptosis and stimulates the expression of stress genes. The structure and role of the prostaglandin A1 was investigated by Bergstr?m and Samuelsson, who shared the 1982 Nobel Prize in Physiology or Medicine for their pioneering work on the eicosanoids. Target(s): CYP4F2; DNA topoisomerase II; HIV-1 transcription; 3ahydroxysteroid dehydrogenase, NADP+-dependent; IkB kinase; Mayaro virus replication; stress-induced NF-kB activation; and virus protein biosynthesis, or translation.

PROSTAGLANDIN A1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


PROSTAGLANDIN A1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 78)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29815 58
Sinoway Industrial co., ltd.
0592-5800732; +8613806035118
xie@china-sinoway.com China 988 58
LEAPCHEM CO., LTD.
+86-852-30606658
market18@leapchem.com China 43340 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20288 58
Aladdin Scientific
+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Sinopharm Chemical Reagent Co,Ltd. 86-21-63210123
sj_scrc@sinopharm.com China 9815 79
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 14055 65
Shanghai Kewel Chemical Co., Ltd. 021-64609169 18901607656
greensnown@163.com China 9906 50
Sigma-Aldrich 021-61415566 800-8193336
orderCN@merckgroup.com China 51456 80

14152-28-4()Verwandte Suche:


  • prostaglandina(sup1)
  • prostaglandine(sup1)-217
  • prostaglandina1syntheticcrystalline
  • (13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1
  • (13E)-(15S)-15-Hydroxy-9-oxoprosta-10,13-dienoate
  • C04685
  • ProstaglandinA1,(13E,15S)-15-Hydroxy-9-oxoprosta-10,13-dien-1-oic acid, PGA1
  • Prostaglandin A1 (25 mg)
  • Prostaglandin Impurity A
  • PGA1 (Prostaglandin A1)
  • prostaglandins A1 synthetic
  • 9-OXO-15S-HYDROXY-PROSTA-10,13E-DIEN-1-OIC ACID
  • [13E,15S]-15-HYDROXY 9-OXOPROSTA-10,13-DIEN-1-OIC ACID
  • PROSTAGLANDINS A1
  • PROSTAGLANDIN A1
  • 13-dien-1-oicacid,15-hydroxy-9-oxo-,(13e,15s)-prosta-1
  • 2-(3-hydroxy-1-octenyl)-5-oxo-3-cyclopentene-1-heptanoicaci
  • pga(sub1)
  • pga(sup1)
  • prostaglandina(sub1)
  • Prostagladin A
  • Alprostadil (Prostaglandin E1) EP Impurity A
  • Prosta-10,13-dien-1-oic acid, 15-hydroxy-9-oxo-, (13E,15S)-
  • Prostaglandin A1 (1578500)
  • Prostaglandin A
  • Prostagladin E1
  • PGA1
  • a.7-[(1R,2S)-2-[(1e,3S)-3-hydroxyoct-1-enyl]-5-oxocyclopent-3-enyl]heptanoicacid(prostaglandina1)
  • Prostaglandin (Alprostadil) EP Impurity A
  • 14152-28-4
  • 33647
  • BioChemical
  • Biochemicals and Reagents
  • Fatty Acids
  • Prostaglandins
  • Lipids
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