(3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one
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- CAS-Nr.
- 34783-48-7
- Englisch Name:
- (3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one
- Synonyma:
- PE-04859989;PF-04859989;PF 04859989,PF04859989;(3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one;2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, (3S)-
- CBNumber:
- CB34749665
- Summenformel:
- C9H10N2O2
- Molgewicht:
- 178.19
- MOL-Datei:
- 34783-48-7.mol
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(3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one Eigenschaften
- Siedepunkt:
- 361.6±52.0 °C(Predicted)
- Dichte
- 1.387±0.06 g/cm3(Predicted)
- pka
- 8.37±0.40(Predicted)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
| H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
| H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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(3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one Chemische Eigenschaften,Einsatz,Produktion Methoden
Enzyminhibitor
This systemically available KAT II inhibitor (FW = 178.19 g/mol; CAS 34783-48-7; IUPAC: (3S)-3-amino-1-hydroxy-3,4-dihydroquinolin-2(1H)- one) irreversibly inhibits kynurenine amino transferase II, or KAT II, with Ki = 23 nM, kinact/Ki 112,000 M–1 s –1 , IC50 = 263 nM, and PartitionCoefficientn-octanol/H2O = 3 x 108. This inhibitor most likely makes an enamine adduct with enzyme-bound pyridoxal-P. Rationale: Kynurenate is a tryptophan-derived endogenous antagonist for glutamate and a7-nicotinic acetylcholine receptors in the brain. Increased levels are observed postmortem in the brains of patients with a range of neurocognitive disorders, including schizophrenia. Kynurenate may well contribute to the cognitive symptoms of these conditions. Pharmacology: PF-04859989 restores glutamate release "transients" evoked by ejections of nicotine into the prefrontal cortex of rats exhibiting elevated kynurenate levels. Systemic administration of PF-04859989 30 min prior to administration of Lkynurenine (but not when administered 30 min after L-kynurenine) restores glutamatergic transients recorded up to 120 min after the administration of the KAT II inhibitor. Furthermore, the KAT-II inhibitor significantly reverses L-kynurenine-induced elevations of brain KYNA levels. The KATII inhibitor does not affect nicotine-evoked glutamatergic transients in rats not pre-treated with L-kynurenine
(3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
(3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 5)Lieferanten
- (3S)-3-amino-1-hydroxy-1,2,3,4-tetrahydroquinolin-2-one
- PF-04859989
- PF 04859989,PF04859989
- 2(1H)-Quinolinone, 3-amino-3,4-dihydro-1-hydroxy-, (3S)-
- PE-04859989
- 34783-48-7
