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TTK21

TTK21 Struktur
709676-56-2
CAS-Nr.
709676-56-2
Englisch Name:
TTK21
Synonyma:
TTK2;TTK21;TTK21(CBP-p300 activator TTK21);Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-;TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
CBNumber:
CB34666838
Summenformel:
C17H15ClF3NO2
Molgewicht:
357.75
MOL-Datei:
709676-56-2.mol

TTK21 Eigenschaften

Siedepunkt:
369.8±42.0 °C(Predicted)
Dichte
1.321±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 3 mg/ml; DMSO: 5 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 2 mg/ml
Aggregatzustand
A crystalline solid
pka
12.22±0.70(Predicted)
Farbe
White to off-white
InChI
InChI=1S/C17H15ClF3NO2/c1-2-9-24-15-6-4-3-5-12(15)16(23)22-11-7-8-14(18)13(10-11)17(19,20)21/h3-8,10H,2,9H2,1H3,(H,22,23)
InChIKey
AQJBXYBDNZHZRE-UHFFFAOYSA-N
SMILES
C(NC1=CC=C(Cl)C(C(F)(F)F)=C1)(=O)C1=CC=CC=C1OCCC

Sicherheit

TTK21 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

TTK21 is an activator of CBP/p300 histone acetyltransferase activity. It activates CBP/p300 histone acetyltransferase activity in a concentration-dependent manner with a maximal effect at a concentration of 275 μM, inducing acetylation of histones H3 and H4 in vitro but not H2B and H2A. TTK21, conjugated to glucose-based carbon nanospheres (CSP), crosses the blood-brain barrier and increases histone acetylation of H2B and H3 as well as H4K12 in mouse frontal cortex and H2B and H3 in the dorsal hippocampus and brainstem. CSP-TTK21 (20 mg/kg) also induces differentiation and maturation of neuronal progenitors in adult mice's subgranular zone of the dentate gyrus. It increases memory duration in the Morris water maze, with mice spending more time in the platform quadrant than untreated mice up to 16 days after learning.

Verwenden

N-[4-Chloro-3-(trifluoromethyl)phenyl]-2-propoxybenzamide was used in preparation of benzamide compounds as modulators of enzymes histone acetyltransferases and chromatin transcription.

TTK21 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TTK21 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 50)Lieferanten
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4575 55
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
  • TTK21
  • Benzamide, N-[4-chloro-3-(trifluoromethyl)phenyl]-2-propoxy-
  • TTK21(CBP-p300 activator TTK21)
  • TTK 21,HAT,histone acetyltransferases,neurogenesis,TTK21,blood–brain barrier,HATs,inhibit,Histone Acetyltransferase,Inhibitor,long-term memory,toxicity,CSP,TTK-21,CBP/p300
  • TTK2
  • 709676-56-2
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