Endosidin 2
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- CAS-Nr.
- 1839524-44-5
- Englisch Name:
- Endosidin 2
- Synonyma:
- Endosidin 2;Endosidin-2
(ES-2);Endosidin-2, 10 mM in DMSO;(E)-3-Fluoro-N'-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide;3-fluoro-N'-[(E)-(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]benzohydrazide;3-fluoro-benzoicacid,(2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide;Benzoic acid, 3-fluoro-, (2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide
- CBNumber:
- CB34666449
- Summenformel:
- C15H12FIN2O3
- Molgewicht:
- 414.17
- MOL-Datei:
- 1839524-44-5.mol
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Endosidin 2 Eigenschaften
- Dichte
- 1.67±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- Soluble in DMSO (greater than 40 mg/ml), in DMF (up to 35 mg/ml) or in Ethanol (up to 10 mg/ml)
- Aggregatzustand
- powder
- pka
- 7.75±0.36(Predicted)
- Farbe
- white to beige
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO, DMF or ethanol may be stored at -20°C for up to 1 month.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Endosidin 2 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Endosidin 2 binds to the EXO70 (exocyst component of 70 kDa) subunit of the exocyst complex, resulting in inhibition of exocytosis and endosomal recycling in both plant and human cells and enhancement of plant vacuolar trafficking. A valuable tool for exocytosis studies.
Biochem/physiol Actions
Endosidin2 is a cell-permeable benzylidene-benzohydrazide based compound that binds to the exocyst component of 70 kDa (EXO70) subunit of exocyst complex (Kd?= 253 μM for interaction with EXO70A1) and reduces exocytosis and endosomal recycling in plant and mammalian cells. Displays good aqueous stability. Endosidin2 has shown to disrupt the trafficking of proteins between the plasma membrane and endosome, which leads to enhanced trafficking to the vacuole for degradation. It is reported to inhibit the recycling of endocytosed transferrin to plasma membrane in HeLa cells, and can target multiple isoforms of EXO70 in mammals, resulting in misregulation of exocytosis.
Endosidin 2 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Endosidin 2 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 25)Lieferanten
1839524-44-5()Verwandte Suche:
- Endosidin 2
- Endosidin-2
(ES-2)
- Benzoic acid, 3-fluoro-, (2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide
- 3-fluoro-benzoicacid,(2E)-2-[(4-hydroxy-3-iodo-5-methoxyphenyl)methylene]hydrazide
- (E)-3-Fluoro-N'-(4-hydroxy-3-iodo-5-methoxybenzylidene)benzohydrazide
- 3-fluoro-N'-[(E)-(4-hydroxy-3-iodo-5-methoxyphenyl)methylidene]benzohydrazide
- Endosidin-2, 10 mM in DMSO
- 1839524-44-5
