7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

7α-hydroxy Cholesterol-d₇ is intended for use as an internal standard for the quantification of 7α-hydroxy cholesterol by GC- or LC-MS. 7α-hydroxy Cholesterol is an oxysterol and a precursor in the biosynthesis of the bile acids cholic acid (CA; ) and chenodeoxycholic acid (CDCA; ). It is formed via the oxidation of cholesterol by cholesterol 7α-hydroxylase/CYP7A1 in rat liver microsomes. 7α-hydroxy Cholesterol (40 μM) increases levels of the adhesion molecules ICAM-1, VCAM-1, and E-selectin in human umbilical vein endothelial cells (HUVECs). It increases secretion of chemokine (C-C motif) ligand 2 (CCL2) and matrix metalloproteinase-9 (MMP-9) in serum-deprived THP-1 cells when used at a concentration of 5 μg/ml. 7α-hydroxy Cholesterol has been found in macrophages isolated from atherosclerotic lesions in rabbits fed a high-cholesterol diet.

Verwenden

7α-hydroxycholesterol-d7 has been used as an internal standard for cholesterol and oxysterol measurement by gas chromatography-mass spectrometry (GC/MS).

Allgemeine Beschreibung

7α-hydroxycholesterol is an oxysterol synthesized by the oxidation of the side chain of cholesterol. It is the precursor of bile acid.

7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52925	58
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9679	58
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18043	56
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Codow Chemical Co.,Ltd.	18620099427	amy@howeipharm.com	China	17687	55
Shanghai EFE Biological Technology Co., Ltd.	021-65675885 18964387627	info@efebio.com	China	9806	58
Chengdu Dianchun Technology Co., Ltd	400-1166-196 18502815961	cdhxsj@163.com	China	14603	60
Shanghai Jizhi Biochemical Technology Co. Ltd.	4009004166/18616739031 18616739031	3007523370@qq.com	China	52693	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774	sales@glpbio.cn	China	6777	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11217	58

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• 7ALPHA-HYDROXYCHOLESTEROL-25,26,26,26,27,27,27-D7
• cholest-5-en-3,7α-diol-d7
• CHOLEST-5-EN-3,7Α-DIOL-D7;7Α-HYDROXYCHOLESTEROL-D7
• 7alpha-hydroxycholesterol-d7
• 7α-hydroxy Cholesterol-d7
• 7α-Hydroxycholesterol-25?26?26?26?27?27?27-[d7]
• Cholesterol Impurity 37
• cholest-5-en-3?,7α-diol-d7
• cholest-5-en-3β,7α-diol-d7
• 349553-94-2
• C26H37D7O2
• Hydroxycholesterol