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(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Struktur
1012341-48-8
CAS-Nr.
1012341-48-8
Englisch Name:
(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
Synonyma:
E)-5-([1;LCZ-696-013;LCZ696 impurities2;LCZ-696 Impurity 58;LCZ696 impurities114;LCZ696 Intermediate II;(R,E)-5-([1,1'-BiphenyL;Sacubitril intermediates;)-4-((tert-butoxycarbonyL;LCZ696(valsartan + sacubitril) impurity 30
CBNumber:
CB32723687
Summenformel:
C23H27NO4
Molgewicht:
381.46
MOL-Datei:
1012341-48-8.mol

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Eigenschaften

Schmelzpunkt:
188 - 191°C
Siedepunkt:
595.6±50.0 °C(Predicted)
Dichte
1.132±0.06 g/cm3(Predicted)
Dampfdruck
8.4-839.931Pa at 20℃
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMSO (Slightly), Methanol (Slightly)
pka
4.67±0.19(Predicted)
Aggregatzustand
Solid
Farbe
White to Off-White
InChI
InChI=1S/C23H27NO4/c1-16(21(25)26)14-20(24-22(27)28-23(2,3)4)15-17-10-12-19(13-11-17)18-8-6-5-7-9-18/h5-14,20H,15H2,1-4H3,(H,24,27)(H,25,26)/b16-14+/t20-/m0/s1
InChIKey
JXTNUXJSXXIIFE-VISDOYDDSA-N
SMILES
C(O)(=O)/C(/C)=C/[C@H](NC(OC(C)(C)C)=O)CC1=CC=C(C2=CC=CC=C2)C=C1
LogP
2.2-3.6 at 25℃ and pH2.5-7
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

(R,E)-5-([1,1-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-methylpent-2-enoic Acid is used in preparation of sacubitril intermediate using Nickel Salt catalyst.

(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 218)Lieferanten
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ChemExpress
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  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
  • (2E,4R)-5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-Pentenoic acid
  • 5-Biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-2-enoic acid
  • 2-Pentenoic acid, 5-[1,1'-biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-, (2E,4R)-
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid###1012341-48-8 enantioMer
  • (R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino)-2-methylpent-2-enoic acid
  • (R,E)-5-(biphenyl-4-yl)-4-(tert-butoxycarbonylamino)
  • (2E,4R)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid AHU83
  • 1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
  • E)-5-([1
  • (R, E) -5-([1,1'-Biphenyl] -4-yl) -4-((tert-butoxycarbonyl) amino) -2-methyl-2-pentenoic acid
  • LCZ696(valsartan + sacubitril) impurity 30
  • (2E,4R)-5-{[1,1'-biphenyl]-4-yl}-4-{[(tert-butoxy)carbonyl]amino}-2-methylpent-2-enoic acid
  • (R,E)-5-([1,1'-BiphenyL
  • )-4-((tert-butoxycarbonyL
  • LCZ696 intermediates,(R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert- butoxycarbonyl)aMino)-2-Methylpent- 2-enoic acid
  • (E,4r)-2-methyl-4-[(2-methylpropan-2-yl)oxycarbonylamino]-5-(4-phenylphenyl)pent-2-enoic acid
  • (R,E)-5-([1,1'-Biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoic acid (LCZ696 Impurity)
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino...
  • LCZ696 impurities114
  • LCZ696 impurities2
  • (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acidQ: What is (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid Q: What is the CAS Number of (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid Q: What is the storage condition of (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid Q: What are the applications of (R)-5-biphenyl-4-yl-4-tert-butoxycarbonylamino-2-methyl-pent-(E)-2-enoic acid
  • LCZ-696 Impurity 58
  • 2-Amino-4-(4-fluorbenzylamino)-3-ethoxycarbonylaminobenzene
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
  • LCZ-696-013
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)amino)-2-methylpent-2-enoicaci
  • LCZ696 Intermediate II
  • Sacubitril intermediates
  • (R,E)-5-([1,I'-biphenyl]-4-yl)-4-((tert-butoxycarbony 1)amino)-2-methylpent-2-enoic acid
  • (R,E)-5-([1,1'-biphenyl]-4-yl)-4-((tert-butoxycarbonyl)aMino)-2-Methylpent-2-enoic acid
  • (2E, 4R) -5- [1,1 '- biphenyl] -4-yl-4- [[tert butoxycarbonyl] amino] -2-methyl-2-pentenoic acid
  • (2E,4R)-5-[1,1'-Biphenyl]-4-yl-4-[[(1,1-dimethylethoxy)carbonyl]amino]-2-methyl-2-pentenoic acid
  • 1012341-48-8
  • 1212341-48-8
  • LCZ696
  • intermediate
  • intermediates
  • 1012341-48-8
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