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AMG 925

AMG 925 Struktur
1401033-86-0
CAS-Nr.
1401033-86-0
Englisch Name:
AMG 925
Synonyma:
FLX925;FLX-925;AMG 925;CS-1594;FLX 925.;AMG 925 (FLX925;FLX925 (AMG-925);AMG 925;AMG925;AMG-925;AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.;2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-
CBNumber:
CB32685918
Summenformel:
C26H29N7O2
Molgewicht:
471.55
MOL-Datei:
1401033-86-0.mol

AMG 925 Eigenschaften

Siedepunkt:
712.3±70.0 °C(Predicted)
Dichte
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
insoluble in DMSO; insoluble in H2O; insoluble in EtOH
Aggregatzustand
solid
pka
13.41±0.10(Predicted)
Farbe
Light yellow to yellow

Sicherheit

AMG 925 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AMG 925 is a dual inhibitor of FMS-related tyrosine kinase 3 (FLT3) and cyclin-dependent kinase 4 (Cdk4; IC50s = 1 and 3 nM, respectively). It is selective for FLT3 and Cdk4 over Cdk1 (IC50 = 2.22 μM). AMG 925 also binds to FLT3ITD, FLT3D835Y, FLT3D835H, FLT3K663Q, and FLT3N841I (Kds = 1-4 nM). It inhibits proliferation of MOLM-13, COLO 205, and U937 cancer cells (IC50s = 19, 55, and 52 nM, respectively). AMG 925 (50, 75, and 150 mg/kg) reduces intratumor levels of pSTAT5 and pRb and inhibits tumor growth in a MOLM-13 acute myeloid leukemia (AML) mouse xenograft model.

AMG 925 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

2,4-Pyrimidinediamine, N4-(trans-4-methylcyclohexyl)- 1401033-82-6 2,4-Pyrimidinediamine, 5-iodo-N4-(trans-4-methylcyclohexyl)- 9H-Pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-amine, 9-(trans-4-methylcyclohexyl)- 2-methylpropan-2-yl 2-({9-[(1r,4r)-4-methylcyclohexyl]pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl}amino)-5,6,7,8-tetrahydropyrido[4,3-b]pyridine-6-carboxylate trans-4-Methylcyclohexyl amine tert-butyl 2-chloro-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate trans-4-Methylcyclohexylamine hydrochloride 2-CHLORO-5,6,7,8-TETRAHYDRO-1,6-NAPHTHYRIDINE HYDROCHLORIDE Glykolsaeure 3-Fluorpyridin

Downstream Produkte

AMG 925 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 67)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
BOC Sciences 		+1-631-485-4226
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TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. 17702719238 17702719238
 sales@sun-shinechem.com China 993 64
Dalian Meilun Biotech Co., Ltd. 0411-62910999 13889544652
 sales@meilune.com China 4727 58
Shanghai Topbiochem Technology Co., Ltd 021-58170097
info@topbiochem.com China 9478 58
Haoyuan Chemexpress Co., Ltd. 021-58950125
info@chemexpress.com China 7552 61
  • AMG 925
  • 1-[7,8-Dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxyethanone
  • 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-
  • Ethanone, 1-[7,8-dihydro-2-[[9-(trans-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl]amino]-1,6-naphthyridin-6(5H)-yl]-2-hydroxy-
  • AMG 925;AMG925;AMG-925
  • CS-1594
  • 2-Hydroxy-1-(2-((9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4',3':4,5]pyrrolo[2,3-d]pyrimidin-2-yl)amino)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl)ethanone
  • AMG925; AMG-925; AMG 925; FLX925; FLX-925; FLX 925.
  • FLX 925.
  • FLX925
  • FLX-925
  • AMG 925 (FLX925
  • FLX925 (AMG-925)
  • CDK,AMG 925,Cluster of differentiation antigen 135,FLT3,Cyclin dependent kinase,inhibit,CD135,AMG-925,AMG925,Inhibitor,Fms like tyrosine kinase 3
  • 1401033-86-0
  • C26H29N7O2
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