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NSI-189

NSI-189 Struktur
1270138-40-3
CAS-Nr.
1270138-40-3
Englisch Name:
NSI-189
Synonyma:
CS-1018;NSI-189;NIS-?189;NSI-189 base;NSI-189, >=98%;NSI189; NSI 189;NSI-189 free base;NSI-189 and its phosphate;(4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl];(4-BENZYLPIPERAZIN-1-YL)(2-(ISOPENTYLAMINO)PYRIDIN-3-YL)METHANONE
CBNumber:
CB32672989
Summenformel:
C22H30N4O
Molgewicht:
366.5
MOL-Datei:
1270138-40-3.mol

NSI-189 Eigenschaften

Siedepunkt:
534.7±50.0 °C(Predicted)
Dichte
1.134±0.06 g/cm3(Predicted)
storage temp. 
-20°C
L?slichkeit
Soluble in DMSO
pka
6.18±0.10(Predicted)
Aggregatzustand
A crystalline solid
Farbe
White to yellow
maximale Wellenl?nge (λmax)
254 nm
InChI
InChI=1S/C22H30N4O/c1-18(2)10-12-24-21-20(9-6-11-23-21)22(27)26-15-13-25(14-16-26)17-19-7-4-3-5-8-19/h3-9,11,18H,10,12-17H2,1-2H3,(H,23,24)
InChIKey
DYTOQURYRYYNOR-UHFFFAOYSA-N
SMILES
C(C1=CC=CN=C1NCCC(C)C)(N1CCN(CC2=CC=CC=C2)CC1)=O
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit

NSI-189 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

NSI-189 is an investigational drug being developed by Neuralstem Inc., a biopharmaceutical company. NSI-189 is a small molecule in clinical development for major depressive disorder (MDD) and in preclinical development for Angelman syndrome, irradiation-induced cognitive impairment, Type 1 and Type 2 diabetes, and stroke. NSI-189 was studied in phase I and II clinical trials for the treatment of major depressive disorder. As of July 2017, NSI-189 has failed to meet effectiveness outcomes for depression in phase II trials.

Verwenden

NSI-189 is an experimental, potential antidepressant, for the treatment for major depressive disorder (MDD), as well as for cognitive impairment and neurodegeneration.

Nebenwirkungen

NSI 189 is not approved by the FDA, and there is not enough scientific information available to verify its safety. To lessen any potential side effects, it is advisable to only take the lowest possible dose of the compound at first in order to judge how it will affect the body. The possible side effects of this compound include nausea, fatigue, heart palpitations, headache, increased anxiety, visual perception changes, loss of memory, dissociation, decreased appetite, increased heart rate, delirium, and a drop in blood sugar.
As there have been no long term studies for this compound, the long term effects and overall safety are unknown. For this reason, it is not suggested to take the compound if an individual is pregnant or breastfeeding. It is also not advisable to take the compound if an individual is taking a prescription medication for the treatment of depression, neuropathy, or if they have low blood sugar.

Clinical claims and research

NSI-189 completed a phase I clinical trial for MDD in 2011, where it was administered to 41 healthy volunteers.A phase Ib clinical trial for treating MDD in 24 patients started in 2012 and completed in July 2014, with results published in December 2015. In July 2017, it was announced that a phase II clinical trial with 220 patients failed to meet its primary effectiveness endpoint in MDD.Upon the announcement, Neuralstem stock plummeted by 61%.More detailed analysis of the trial results was released in December 2017 and January 2018. The compound has gone through phase I and II clinical trials for its antidepressant properties, but the phase II trial failed to meet effectiveness outcomes. It is currently still being studied as a possible treatment for other conditions.

Mode of action

NSI-189 is a compound that may increase the birth of new neurons (neurogenesis) in the brain area known as the hippocampus. It works by stimulating the growth of new brain cells and nerve cells through a process called neurogenesis. The neurogenesis appears to affect the hippocampus primarily, which is responsible for learning, memory, and emotion. Scientists believe the compound has the potential to treat various neurological and nerve conditions.

NSI-189 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


NSI-189 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 168)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Langyou International Trading Co., Ltd
+86-18874586545 +86-18874586545
linda@xrdchem.cn China 196 58
Wuhan Nutra Biotechnology Co.,Ltd
+8617786394783
nutrabiotech@outlook.com China 300 58
Wuhan senwayer century chemical Co.,Ltd
+undefined-27-86652399 +undefined13627115097
market02@senwayer.com China 904 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Hubei Chuyan Biopharmaceutical Co., Ltd
+1-027-87896938 +15172028168
chuyan@chuyan.co China 24 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
Hebei Zhuanglai Chemical Trading Co.,Ltd
+8613343047651
admin@zlchemi.com China 3002 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902
angelia@hbmojin.com China 1176 58

  • NSI-189
  • (4-BENZYLPIPERAZIN-1-YL)-[2-(3-METHYLBUTYLAMINO)PYRIDIN-3-YL]METHANONE
  • (4-BENZYLPIPERAZIN-1-YL)(2-(ISOPENTYLAMINO)PYRIDIN-3-YL)METHANONE
  • [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone
  • [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone NSI189
  • NSI-189 [2-[(3-Methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]methanone
  • NSI-189, >=98%
  • (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl]
  • (4-benzylpiperazin-1-yl)-[2-(3-methylbutylamino)pyridin-3-yl],NSI-189
  • NSI-189 free base
  • CS-1018
  • NSI-189 base
  • NSI189; NSI 189
  • Methanone, [2-[(3-methylbutyl)amino]-3-pyridinyl][4-(phenylmethyl)-1-piperazinyl]-
  • NIS-?189
  • NSI-189 (4-benzylpiperazin-1-yl)-[2- (3-methylbutylamino)pyridin- 3-yl]methanone
  • NSI-189 and its phosphate
  • 1270138-40-3
  • 50922-68-1
  • Inhibitors
  • API
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