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2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- Struktur
1010096-65-7
CAS-Nr.
1010096-65-7
Englisch Name:
2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-
Synonyma:
AM6701;LY2183240 2’LY2183240 2’-isomer;LY2183240 2’-isomer Exclusive;LY2183240 2'-isomer Exclusive;5-([1,1-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide;2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-
CBNumber:
CB32667875
Summenformel:
C17H17N5O
Molgewicht:
307.35
MOL-Datei:
1010096-65-7.mol

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- Eigenschaften

Siedepunkt:
506.1±53.0 °C(Predicted)
Dichte
1.21±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 3 mg/ml; DMSO: 2 mg/ml; Ethanol: 10 mg/ml; Ethanol:PBS(pH 7.2) (1:5): 0.1 mg/ml
Aggregatzustand
A crystalline solid
pka
-1.73±0.12(Predicted)
Farbe
Light yellow to yellow

Sicherheit

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

LY2183240 is a potent, competitive small molecule inhibitor of anandamide uptake (IC50 = 270 pM; Ki = 540 pM) and hydrolysis. It has been shown to increase anandamide levels in rat cerebellum (ED50 = 1.37 mg/kg) and displays dose-dependent efficacy (3-30 mg/kg) in several rodent models of persistent pain. LY2183240 2’-isomer is a less potent, 2,5-regioisomer of LY2183240 that inhibits anandamide hydrolysis and uptake with IC50 values of 33 and 998 nM, respectively.

Verwenden

5-([1,1''-Biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide is an inhibitor of human monoacylglycerol lipase (hMGL).

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl- Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 2H-Tetrazole-2-carboxaMide, 5-([1,1'-biphenyl]-4-ylMethyl)-N,N-diMethyl-
  • LY2183240 2’-isomer
  • LY2183240 2'-isomer Exclusive
  • 5-([1,1-biphenyl]-4-ylmethyl)-N,N-dimethyl-2H-tetrazole-2-carboxamide
  • LY2183240 2&rsquo
  • AM6701
  • LY2183240 2’-isomer Exclusive
  • 1010096-65-7
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