2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
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- CAS-Nr.
- 32384-65-9
- Englisch Name:
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- Synonyma:
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone;Dagliptin Impurity;oxy)-6-((triMethyL;Cagliflozin Impurity 9;Englitazinintermediate;Dapagliflozin Impurity 12;Canagliflozin Related Impurity 9;(3R,4S,5R,6R)-3,4,5-tris(triMethyL;Canagliflozin Impurity 9(Dagelin impurity 11);Boronicacid,B-(1,6-dihydro-6-oxo-9-pyridinyl)-
- CBNumber:
- CB32610563
- Summenformel:
- C18H42O6Si4
- Molgewicht:
- 466.87
- MOL-Datei:
- 32384-65-9.mol
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2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Eigenschaften
- Siedepunkt:
- 417℃
- Dichte
- 0.97
- Flammpunkt:
- 171℃
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- L?slichkeit
- Chloroform (Sparingly), Ethyl Acetate (Slightly), Methanol (Slightly)
- Aggregatzustand
- Oil
- Farbe
- Colourless to Pale Yellow
- Stabilit?t:
- Moisture Sensitive
- InChI
- InChI=1/C18H42O6Si4/c1-25(2,3)20-13-14-15(22-26(4,5)6)16(23-27(7,8)9)17(18(19)21-14)24-28(10,11)12/h14-17H,13H2,1-12H3/t14-,15-,16+,17-/s3
- InChIKey
- VNGTZLYNGGLPIZ-NELUYGJANA-N
- SMILES
- O([C@@H]1[C@H](C(=O)O[C@H](CO[Si](C)(C)C)[C@H]1O[Si](C)(C)C)O[Si](C)(C)C)[Si](C)(C)C |&1:1,2,6,13,r|
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Pale yellow oil
Verwenden
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is an antidiabetic agent and an intermediate of Dapagliflozin (D185370). 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone acts as a reagent in the synthesis of trans-cyclohexane-bearing C-glucose as sodium glucose co-transporter 2 inhibitors.
Synthese
At present, the publicly reported synthesis process of 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone is mainly prepared by the synthesis of D-gluconolactone and trimethylsilyl chloride in the presence of an acid-binding agent or the preparation of D-gluconolactone and hexamethyldisilazane in dichloromethane reflux. The former has problems such as high pH requirements, low atom economy, and severe pollution. In contrast, the latter has such problems as the large amount of hexamethyldisilazane used, the strong volatility of dichloroethane, and severe pollution. Therefore, Li et al. developed a method for preparing 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone, comprising the following operations: reacting D-gluconolactone with hexamethyldisilazane in an ionic liquid at standard pressure, and removing the ionic liquid by reduced pressure distillation after the reaction is completed to obtain 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone; the cation in the ionic liquid is an alkyl imidazolium ion, and the anion in the ionic liquid is hexafluorophosphate, tetrafluoroborate, tetrachloroaluminate or chloride ion.
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 482)Lieferanten
32384-65-9()Verwandte Suche:
- (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one
- (3R,4S,5R,6R)-3,4,5-Tris[(trimethylsilyl)oxy]-6-[[(trimethylsilyl)oxy]methyl]tetrahydropyran-2-one
- D-2,3,4,6-Tetrakis-O-(trimethylsilyl)-gluconic acid delta-lactone
- 2,3,4,6-Tetrakis-O-triMethylsilyl-D-gluconolactoe
- D-Gluconic acid, 2,3,4,6-tetrakis-O-(triMethylsilyl)-, d-lactone
- 2,3,4,6-tetrakis-O-trimethylsilyl-D-glucono1,5 lactone
- (3R,5R,6R)-3,4,5-Tris((trimethylsilyl)oxy)-6-(((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one
- (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan-2-one
- 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone
- Dapagliflozin Impurity 12
- Cagliflozin Impurity 9
- 32384-65-9 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan-2-one 32384-65-9
- (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyl)oxy)-6-((trimethylsilyl)oxy)methyl)tetrahydro-2H-pyran-2-one 97%
- 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-delta-lactone
- (3R,4S,5R,6R)-3,4,5-tris(trimethylsilyloxy)-6-(trimethylsilyloxymethyl)oxan
- Dagliptin Impurity
- (3R,4S,5R,6R)-3,4,5-tris(triMethyL
- oxy)-6-((triMethyL
- Canagliflozin Related Impurity 9
- 2,3,4,6, tetrakis-O-(trimethylsilyl)-D-lactone,
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone(For export only)
- (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one ISO 9001：2015 REACH
- Empagliflozin intermediates，2,3,4,6-Tetrakis-O-trimethylsilyl-D- gluconolactone
- 2,3,4,5-Tetrakis-O-trimethylsilyl-D-gluconolactone
- 5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one
- D-Gluconic acid, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, .delta.-lactone
- 2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactoneQ: What is
2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone Q: What is the CAS Number of
2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone Q: What is the storage condition of
2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone Q: What are the applications of
2,3,4,6-Tetra-O-(trimethylsilyl)-D-glucono-1,5-lactone
- 2,3,4,6-Tetrakis-O-trimethylsilyl-D-gluconolactone
- 3,4,5-Tris[(trimethyl silyl)oxy]-6-{[(trimethylsilyl)oxy]methyl}tetrahydro-2H-pyron-2-one
- Englitazinintermediate
- Boronicacid,B-(1,6-dihydro-6-oxo-9-pyridinyl)-
- (3R,4S,5R,6R)-3,4,5-tri ((trimethyl)
Methylsilane)oxy)-6-(((trimethylmethylmethyl
Silic alkyl)oxy group) field group) four atmosphere-2H-pyrid
N?m-2-ketone
- (3R, 4S, 5R, 6R)-3,4,5-tri ((trimethyl)Methylsilane)oxy)-6-(((trimethylmethylmethyl
Silicyl)oxy)methyl)tetrahydr-2H-pyridium
N?m-2-ketone
- (3R,4S,5R,6R)-3,4,5-tris(triMethylsilyloxy)-6-((triMethylsilyloxy)Methyl)tetrahydro-2H-pyran-2-one,95%
- 2,3,4,6- tetra -O- trimethylsilyl -D- gluconolactone
- D-Gluconic acid, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, δ-lactone
- (3R,4S,5R,6R)-3,4,5-tris(TMS-oxy)-6-[(TMS-oxy)methyl]tetrahydro-2H-pyran-2-one/D-Gluconic acid, 2,3,4,6-tetrakis-O-(trimethylsilyl)-, δ-lactone
- 2,3,4,6-tetra-O-Trimethylsilyl-beta-D-glucolactone
- Canagliflozin Impurity 9(Dagelin impurity 11)
- 2,3,4,6-tetra-O-trimethylsilyl-β-d-
gluconolactone
- (3R,4S,5R,6R)-3,4,5-
Tri[(trimethylsilyl)oxy]-6- [[(Trimethylsilyl)oxy] methyl]tetrahydro-2H-pyran- 2-one
- 2,3,4,6-tetra-O-Trimethyl silyl-beta-D-glucolacto Commercial
- 2,3,4,6-tetrakis-O-(trimethylsilyl)-D-glocono-1,5-Lactone
- (2R,3R,6S)-2-(acetoxymethyl)-6-(3-((5-(4-fluorophenyl)thiophen-2-yl)methyl)-2-methylphenyl)tetrahydro-2H-pyran-3,4,5-triyl triacetate
- (3R,4S,5R,6R)-3,4,5-tris[(trimethylsilanyl)oxy]-6-{[(trimethylsilanyl)oxy]methyl}tetrahydro-2H-pyran-2-one
- 32384-65-9
- 32384-69-5
- C18H42O6Si4
- 32384-65-9
