CHIR-124
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- CAS-Nr.
- 405168-58-3
- Englisch Name:
- CHIR-124
- Synonyma:
- CS-2141;CHIR-124;CHIR-124 USP/EP/BP;CHIR-124
(CHIR124;4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one;2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylaMino]-3-(1H-benziMidazol-2-yl)-6-chloro-;(S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one , CHIR-124;Platelet-derived growth factor receptor,PDGFR,CHIR-124,Checkpoint Kinase (Chk),CD135,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,inhibit,Apoptosis,Inhibitor,FLT3
- CBNumber:
- CB32561465
- Summenformel:
- C23H22ClN5O
- Molgewicht:
- 419.91
- MOL-Datei:
- 405168-58-3.mol
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CHIR-124 Eigenschaften
- Dichte
- 1.46
- storage temp.
- Store at -20°C
- L?slichkeit
- insoluble in H2O; ≥10.5 mg/mL in DMSO; ≥2.61 mg/mL in EtOH with gentle warming
- Aggregatzustand
- solid
- pka
- 9.00±0.70(Predicted)
- Farbe
- Light yellow to brown
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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Sicherheit |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P305+P351+P338 |
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CHIR-124 Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Checkpoint kinase 1 (Chk1) regulates S and G
2-M phase cell cycle checkpoints in response to DNA damage. CHIR124 is a cell-permeable, quinolone-based inhibitor of Chk1 (IC
50 = 0.3 nM
in vitro). It demonstrates high selectivity for Chk1 by displaying inhibitory values 2,000-fold higher against Chk2 (IC
50 = 0.7 μM). In synergy with topoisomerase I poisons or ionizing radiation, CHIR124 can inhibit the growth of p53-mutant solid tumor cells both
in vitro and in a xenograft model, potentiating tumor apoptosis.
Verwenden
CHIR 124 is a cell-permeable molecule with a quinolone-based structure. It inhibits checkpoint kinase 1 (Chk1) which regulates S and G2-M cekk cycle checkpoints in response to DNA damage. Application towards inhibition of tumor cell growth.
CHIR-124 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CHIR-124 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 85)Lieferanten
405168-58-3()Verwandte Suche:
- CHIR-124
- 2(1H)-Quinolinone, 4-[(3S)-1-azabicyclo[2.2.2]oct-3-ylaMino]-3-(1H-benziMidazol-2-yl)-6-chloro-
- 4-[((3S)-1-Azabicyclo[2.2.2]oct-3-yl)amino]-3-(1H-benzimidazol-2-yl)-6-chloroquinolin-2(1H)-one
- CS-2141
- CHIR-124
(CHIR124
- CHIR-124 USP/EP/BP
- Platelet-derived growth factor receptor,PDGFR,CHIR-124,Checkpoint Kinase (Chk),CD135,Fms like tyrosine kinase 3,Cluster of differentiation antigen 135,inhibit,Apoptosis,Inhibitor,FLT3
- (S)-3-(1H-Benzo[d]imidazol-2-yl)-6-chloro-4-(quinuclidin-3-ylamino)quinolin-2(1H)-one , CHIR-124
- 405168-58-3
- Inhibitors