CAL-101
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- CAS-Nr.
- 870281-82-6
- Englisch Name:
- CAL-101
- Synonyma:
- Idelalisib(CAL-101);-101;CS-34;GS1101;AL-101;CAL-11;CAL-101;CAL-101 1KG;CAL101,CAL-101;CAL-101, >=98%
- CBNumber:
- CB32538915
- Summenformel:
- C22H18FN7O
- Molgewicht:
- 415.42
- MOL-Datei:
- 870281-82-6.mol
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CAL-101 Eigenschaften
- Schmelzpunkt:
- 250-252oC
- Siedepunkt:
- 733.4±70.0 °C(Predicted)
- Dichte
- 1.47
- storage temp.
- -20°C
- L?slichkeit
- Soluble in DMSO (>25 mg/ml)
- Aggregatzustand
- White solid.
- pka
- 10.00±0.10(Predicted)
- Farbe
- White
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
- InChIKey
- IFSDAJWBUCMOAH-HNNXBMFYSA-N
- SMILES
- N1C2=C(C(F)=CC=C2)C(=O)N(C2=CC=CC=C2)C=1[C@@H](NC1=C2C(=NC=N1)NC=N2)CC
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
|
| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H372 |
Sch?digt bei Hautkontakt und Verschlucken die Organe bei l?ngerer oder wiederholter Exposition. |
Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P314, P501 |
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| Sicherheit |
| P260 |
Dampf/Aerosol/Nebel nicht einatmen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P314 |
Bei Unwohlsein ?rztlichen Rat einholen / ?rztliche Hilfe hinzuziehen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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CAL-101 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
CAL-101 is a PI3K/mTOR pathway inhibitor used in the treatment of myeloid leukemia through sensitizing the cells to combatting drugs. Potent PI3K-p110-delta inhibitor.
Definition
ChEBI: A member of the class of quinazolines that is 5-fluoro-3-phenylquinazolin-4-one in which the hydrogen at position 2 is replaced by a (1S)-1-(3H-purin-6-ylamino)propyl group. used for for the treatment of refractory indol
nt non-Hodgkin's lymphoma and relapsed chronic lymphocytic leukemia.
in vitro
CAL-101 (Idelalisib) is a highly selective and potent p110δ inhibitor (EC50=8 nM). Greater selectivity (400- to 4000-fold) is seen against related kinases C2β, hVPS34, DNA-PK, and mTOR, whereas no activity is observed against a panel of 402 diverse kinases at 10 μM. CAL-101 reduces PDGF-induced pAkt by only 25% at 10 μM. Idelalisib (CAL-101) inhibits LPA-induced pAkt with an EC50 of 1.9 μM. Idelalisib (CAL-101) blocks Fc?RI p110δ-mediated CD63 expression with an EC50 of 8 nM, whereas formyl-methionyl-leucyl-phenylalanine activation of p110γ is inhibited with an EC50 of 3 μM. Thus, CAL-101 has 240- to 2500-fold selectivity in cell-based assays for p110δ over the other class I PI3K isoforms. CAL-101Idelalisib (CAL-101)-induced apoptosis of chronic lymphocytic leukemia (CLL) cells is significant compared with vehicle treatment alone (P<0.001). Idelalisib (CAL-101) induces selective cytotoxicity in CLL cells independent of IgVH mutational status or interphase cytogenetics.
CAL-101 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
CAL-101 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 295)Lieferanten
- CAL101,CAL-101
- CAL-101
- GS1101
- CAL-101 (GS-1101)
- 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
- CAL-101 (Idelalisib, GS-1101)
- (S)-2-(1-((9H-Purin-6-yl)aMino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(1H-purin-6-ylaMino)propyl]-
- 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]quinazolin-4-one
- 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone CAL-101 (Idelalisib, GS-1101)
- CAL-101 5-Fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
- CAL-101(IDELALISIB)
AL-101
- CAL-101(IDELALISIB)
- AL-101
- CAL-101, >=98%
- Idelalisib, CAL-101, GS-1101
- 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-quinazolinone
- CAL-101 1KG
- CAL-11
- IDELALISIB; CAL-101; GS-1101; GS 1101; GS1101;CAL101
- CS-34
- Idelalisib (This product is only available in Japan.)
- CAL-101, 99%, a selective p110δ inhibitor
- 4(3H)-Quinazolinone, 5-fluoro-3-phenyl-2-[(1S)-1-(9H-purin-6-ylamino)propyl]-
- -101
- CAL-101 USP/EP/BP
- Idelalisib (CAL101, Zydelig, GS1101)
- 5-Fluoro-3-phenyl-2-[1-(9H-purin-6-ylamino)propyl]-4(3H)-qui...
- Idelalisib(CAL-101)
- Idelalisib,PI3K,CAL101,CAL 101,GS 1101,Phosphoinositide 3-kinase,Autophagy,Inhibitor,inhibit,GS1101
- (S)-2-(1-((9H-Purin-6-yl)ami)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- Dabrafenib Mesilate
- (S)-2-(1-((7H-purin-6-yl)amino)propyl)-5-fluoro-3-phenylquinazolin-4(3H)-one
- Idelalisib, 10 mM in DMSO
- 870281-82-6
- 10870281-82-6
- C22H18FN7O
- Akt
- mTOR
- PI3K
- Inhibitors
- Inhibitor
- API
- API
