5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
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- CAS-Nr.
- 172152-53-3
- Englisch Name:
- 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol
- Synonyma:
- 5-(1H-pyrrol-1-yl)-1H-benzo[d]iMidazole-2-thiol;Ilaprazole Impurity A;Ilaprazole Intermediate 2;Enavogliflozin Impurity 21;Ilaprazole intermediate P-3;5-Pyrrol-1-yl-1H-benzoimidazole-2-thiol;5-(1H-Pyroll-1-yl)-2-Mercaptobenzimidazole;5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole;5-(1H-purrole-1-yl)-2-marcapto- benzimidazole;5-pyrrol-1-yl-1,3-dihydrobenzimidazole-2-thione
- CBNumber:
- CB32521216
- Summenformel:
- C11H9N3S
- Molgewicht:
- 215.27
- MOL-Datei:
- 172152-53-3.mol
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5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Eigenschaften
- Siedepunkt:
- 381.7±44.0 °C(Predicted)
- Dichte
- 1.40
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- Aggregatzustand
- Solid
- pka
- 9.61±0.30(Predicted)
- Farbe
- White to Pale Green
- InChI
- InChI=1S/C11H9N3S/c15-11-12-9-4-3-8(7-10(9)13-11)14-5-1-2-6-14/h1-7H,(H2,12,13,15)
- InChIKey
- YYXGYVYKGRUILQ-UHFFFAOYSA-N
- SMILES
- C1(=S)NC2=CC=C(N3C=CC=C3)C=C2N1
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H332 |
Gesundheitssch?dlich bei Einatmen. |
Akute Toxizit?t inhalativ |
Kategorie 4 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P261, P271, P304+P340, P312 |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole is a pharmaceutical intermediate compound used in the synthesis of various drugs such as ilaprazole, gastric and ulcer drugs.
Synthese
Water (100ml) and anhydrous sodium acetate (16.02g, 0.20mole) were added, and then 2-mercapto-5- aminobenzimidazole (32.27g, 0.20mole),2,5-dimethoxytetrahydrofuran (28.4g, 0.21mole), and acetic acid (100ml) were added. Then, stirring was carried out at 5O℃ for 4 hours. The resultant product was cooled to 50C, and tetrahydrofuran (420ml) was added. The mixture was neutralized with a sodium hydroxide aqueous solution, and water (130ml) was added to carry out layer- separation. Then, an organic layer was washed with a sodium hydroxide aqueous solution. The organic layer was dried by anhydrous magnesium sulfate and concentrated, and then crystallized by ethyl acetate and n-hexane to provide a final compound, that is 5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol. Yield: 35.7g (85%)
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
5-(1H-Pyrrol-1-yl)-1H-benzo[d]imidazole-2-thiol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 203)Lieferanten
172152-53-3()Verwandte Suche:
- 1,3-dihydro-5-(1H-pyrrol-1-yl)-2H-Benzimidazole-2-thione
- 5-pyrrol-1-yl-1,3-dihydrobenzimidazole-2-thione
- 5-(1H-Pyrrol-1-yl)-2-mercaptobenzimidazole
- 2H-Benzimidazole-2-thione, 1,3-dihydro-5-(1H-pyrrol-1-yl)-
- 5-(1H-purrole-1-yl)-2-marcapto- benzimidazole
- 5-(1H-pyrrol-1-yl)-1H-benzo[d]iMidazole-2-thiol
- Ilaprazole Intermediate 2
- 5-Pyrrol-1-yl-1H-benzoimidazole-2-thiol
- 5- (1H pyrrolidine-1-yl) -2-mercaptobenzimidazole
- 5-(1H-Pyroll-1-yl)-2-Mercaptobenzimidazole
- 5-(1H-pyrrol-1-yl)-1H-benzo[d]imidazole-2(3H)-thione
- Ilaprazole intermediate P-3
- Enavogliflozin Impurity 21
- Ilaprazole Impurity A
- 172152-53-3
- 175152-53-3
- 17252-53-3
- 103146-26-8