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Sugammadex sodium

Sugammadex sodium Struktur
343306-79-6
CAS-Nr.
343306-79-6
Englisch Name:
Sugammadex sodium
Synonyma:
ORG;Sugammadex Na;Sugammadex soidum;Sugammadex sodium iMpurity;6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt;6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt;CS-2749;Suga-im D;Suggamadex;madex Sodium
CBNumber:
CB32502868
Summenformel:
C72H104Na8O48S8
Molgewicht:
2177.97
MOL-Datei:
343306-79-6.mol

Sugammadex sodium Eigenschaften

storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
DMF: 2.5 mg/ml; DMSO: 2.5 mg/ml; DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml
Aggregatzustand
A crystalline solid
Farbe
White to off-white
InChIKey
NIOBYNJFPSIMJF-OBHNVPISNA-N
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P261, P285, P304+P341, P342+P311,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P285 Bei unzureichender Belüftung Atemschutz tragen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P304+P341 BEI EINATMEN: Bei Atembeschwerden an die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert
P330 Mund ausspülen.
P342+P311 Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Sugammadex sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.

Chemische Eigenschaften

White to Light yellow powder to crystal.Soluble in water, insoluble in methanol and ethanol.

Verwenden

Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.

Application

Sugammadex sodium is a modified γ-cyclodextrin. It is a selective relaxant binding agent (SRBA) indicated for reversal of neuromuscular block induced by steroid-based muscle relaxants, such as rocuronium bromide and vecuronium bromide. Sugammadex soium forms a complex with the muscle relaxants, and it reduces the amount of them available to bind to nicotinic cholinergic receptors in the neuromuscular junction.

Definition

ChEBI: Sugammadex sodium is an organic sodium salt that is the octasodium salt of sugammadex. Used for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery. It has a role as a neuromuscular agent. It contains a sugammadex(8-).

Nebenwirkungen

The most common adverse effects included coughing, movement, vomiting, dry mouth, dysgeusia, hypotension, parosmia, and a sensation of changed temperature.Sugammadex is recommended for the reversal of neuromuscular blockade induced by rocuronium or vecuronium; it should not be used with other steroidal blocking agents since safety and efficacy data are not available for these situations. It should also not be partnered with non-steroidal neuromuscular blockers such as succinylcholine or benzylisoquinolinium-based drugs. Since sugammadex is predominantly cleared by the kidneys, care should be taken when administering this reversal agent in patients with renal impairment.

Mode of action

Sugammadex Sodium is the sodium salt form of sugammadex, a biologically inert, selective relaxant binding agent (SRBA) composed of a modified, anionic gamma cyclodextrin derivative containing a hydrophilic exterior and a hydrophobic core, with neuromuscular blocking drug (NMBD) reversal activity. Upon administration, the negatively charged carboxyl-thio-ether groups of sugammadex selectively and reversibly bind to the positively charged quaternary nitrogen of a steroidal NMBD, such as rocuronium and vecuronium, which was administered at an earlier time for anesthetic purposes. The encapsulation of the NMBD by sugammadex blocks its ability to bind to nicotinic receptors in the neuromuscular junction and thereby reverses the NMBD-induced neuromuscular blockade.

Sugammadex sodium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sugammadex sodium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 301)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Moxin Chemicals
+8617320513646
mike@molcoo.com China 9457 58
Chengdu Aslee Biopharmaceuticals, Inc.
28-85305008
CHINA 964 58
Biopole Pharmatech Co., Ltd.
+8615151475053
biopole@163.com China 37 58
Hebei Yanxi Chemical Co., Ltd.
+8617531190177
peter@yan-xi.com China 5857 58
shandong perfect biotechnology co.ltd
+86-53169958659 +86-13153181156
sales@sdperfect.com China 294 58
Hebei Xinsheng New Material Technology Co., LTD.
+86-16632316109
xinshengkeji@xsmaterial.com China 1085 58
Hangzhou Hyper Chemicals Limited
+86-0086-57187702781 +8613675893055
info@hyper-chem.com China 295 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2986 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Hangzhou FandaChem Co.,Ltd.
+8615858145714
FandaChem@Gmail.com China 9080 55

343306-79-6()Verwandte Suche:


  • ORG-25969/SugaMMadex
  • Sugammadex IMP
  • US-DMF No.: 033904 ASMF filed
  • 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,...
  • Sugammadex sodium (Org-25969)
  • 6 Sugammadex Sodium
  • Glucose-sodium
  • Sulgeng glucose sodium
  • Sugammadex Sodium intermediate II
  • Sugammadex sodium CAS 343306 79 6
  • Sugammadex sodium USP/EP/BP
  • Sugammadex Octasodium Salt
  • Sugammadex Sudium
  • Sugammadex Sodium Sodium
  • Sugammdaex sodium
  • Sugammadex sodico
  • CS-2749
  • Sugammadex sodium-001
  • Sugammadex Sodium salt
  • Sugammadex soidum 343306-79-6
  • Sugammadex Na
  • ORG
  • Sugammadex soidum
  • 6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt
  • 6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt
  • Sugammadex sodium iMpurity
  • Suga-im D
  • madex Sodium
  • Sugammadex Impurity 26 Sodium salt
  • Shugeng Glucose Sodium
  • Sugamose sodium
  • Sugammadex CAS
  • 6-Per-deoxy-6-per-(2-carboxyethyl)thio-γ-cyclodextrin sodium salt
  • Suggamadex
  • Org25969|||Sugammadex (sodium)
  • 343306-79-6
  • 43306-79-6
  • C72H104Na8O48S8
  • C72H104O48S88Na
  • API
  • 343306-79-6
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