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GW 842166X

GW 842166X Struktur
666260-75-9
CAS-Nr.
666260-75-9
Englisch Name:
GW 842166X
Synonyma:
CS-631;GW 842166;GW 842166X;GW842166X;GW 842166;GW842166X/GW-842166X;GW 842166X USP/EP/BP;2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide;2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide;2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide;5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-
CBNumber:
CB32455643
Summenformel:
C18H17Cl2F3N4O2
Molgewicht:
449.25
MOL-Datei:
666260-75-9.mol

GW 842166X Eigenschaften

storage temp. 
Store at -20°C
L?slichkeit
DMF:20.0(Max Conc. mg/mL);44.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.56(Max Conc. mM)
DMSO:37.77(Max Conc. mg/mL);84.07(Max Conc. mM)
Ethanol:0.3(Max Conc. mg/mL);0.67(Max Conc. mM)
Aggregatzustand
Powder
Farbe
White to off-white
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

GW 842166X Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The peripheral cannabinoid (CB2) receptor is a G protein-coupled receptor (GPCR) that is localized predominantly in immune cells, monocytes, macrophages, and in several peripheral organs and binds the active component of cannabis, Δ9-tetrahydrocannabinol, as well as anandamide, an endogenous CB receptor ligand. GW 842166X is a peripheral cannabinoid (CB2) receptor agonist with ED50 values of 91 and 63 nM in rat and human, respectively. When administered orally to rats in the Freund’s complete adjuvant (FCA) model of inflammatory pain, GW 842166X is highly potent with an ED50 value of 0.1 mg/kg and full reversal of hyperalgesia at 0.3 mg/kg.

Verwenden

GW-842166X is pyrimidine ester based compound that is known as a highly selective CB2 receptor agonist for the treatment of inflammatory and neuropathic pain.

GW 842166X Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

GW 842166X Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 98)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Hubei xin bonus chemical co. LTD 		86-13657291602
linda@hubeijusheng.com CHINA 22963 58
BOC Sciences 		+1-631-485-4226
inquiry@bocsci.com United States 19553 58
career henan chemical co 		+86-0371-86658258 +8613203830695
 factory@coreychem.com China 29810 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250
 1026@dideu.com China 22787 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Sichuan Biosynce Pharmatech Co., Ltd. 		+8619950309693
 diane@biosynce.com China 4871 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57505 58

666260-75-9()Verwandte Suche:

  • GW 842166X
  • GW 842166
  • GW842166X/GW-842166X
  • 2-(2,4-Dichlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid [(tetrahydropyran-4-yl)methyl]amide
  • 2-(2,4-dichlorophenylamino)-N-((tetrahydro-2H-pyran-4-yl)methyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
  • 2-(2,4-dichloroanilino)-N-(oxan-4-ylmethyl)-4-(trifluoromethyl)pyrimidine-5-carboxamide
  • GW842166X;GW 842166
  • CS-631
  • 5-Pyrimidinecarboxamide, 2-[(2,4-dichlorophenyl)amino]-N-[(tetrahydro-2H-pyran-4-yl)methyl]-4-(trifluoromethyl)-
  • GW 842166X USP/EP/BP
  • 666260-75-9
  • C18H17Cl2F3N4O2
  • Inhibitors
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