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3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxo-benzo(c)pyran-7-carbons?ure

CITRININ Struktur
518-75-2
CAS-Nr.
518-75-2
Bezeichnung:
3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxo-benzo(c)pyran-7-carbons?ure
Englisch Name:
CITRININ
Synonyma:
CIT;ANTIMYCIN;CTRO;NSC 186;CITRININ;KIAA0949;Cltrinin;Citriain;CITRININE;Cytrinine
CBNumber:
CB3190931
Summenformel:
C13H14O5
Molgewicht:
250.25
MOL-Datei:
518-75-2.mol

3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxo-benzo(c)pyran-7-carbons?ure Eigenschaften

Schmelzpunkt:
175°C (dec.)
alpha 
D18 -37.4° (c = 1.15 in alc.)
Siedepunkt:
313.38°C (rough estimate)
Dichte
1.37
Brechungsindex
1.4560 (estimate)
Flammpunkt:
2℃
storage temp. 
2-8°C
L?slichkeit
≤2mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide
Aggregatzustand
Crystalline Powder or Flakes
pka
1.52±0.60(Predicted)
Farbe
Yellow
Merck 
13,2351
BRN 
5282243
Stabilit?t:
Hygroscopic
CAS Datenbank
518-75-2(CAS DataBase Reference)
IARC
3 (Vol. 40, Sup 7) 1987
EPA chemische Informationen
Citrinin (518-75-2)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher T
R-S?tze: 23/24/25-40-36/37/38
S-S?tze: 26-36/37/39-45-22-7/9
RIDADR  UN 3462 6.1/PG 3
WGK Germany  3
RTECS-Nr. DJ2275000
HazardClass  6.1(a)
PackingGroup  II
HS Code  29419090
Giftige Stoffe Daten 518-75-2(Hazardous Substances Data)
Toxizit?t LD50 in mice, rats (mg/kg): 35, 67 i.p. (Ambrose, De Eds)
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H351 Kann vermutlich Krebs verursachen. Karzinogenit?t Kategorie 2 Warnung P201, P202, P281, P308+P313, P405,P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P261 Einatmen von Staub vermeiden.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxo-benzo(c)pyran-7-carbons?ure Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R23/24/25:Giftig beim Einatmen, Verschlucken und Berührung mit der Haut.
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S22:Staub nicht einatmen.
S7/9:Beh?lter dicht geschlossen an einem gut gelüfteten Ort aufbewahren.

Chemische Eigenschaften

yellow crystalline powder or flakes

Verwenden

Citrinin is a quinonemethine mycotoxin produced by diverse fungi including Aspergillus and Penicillium. Citrinin has been extensively investigate, and is a potent nephrotoxin with hepatoxic and teratogenic activity. Citrinin is the causative agent of Balkan nephropathy and yellow rice fever in humans. At the molecular level, citrinin exhibits a range of effects including free radical damage to DNA and disruption of mitochondrial membrane-bound enzymic activities and structural integrity. Specifically, citrinin is an inhibitor of NADH dehydrogenase in the mitochondrial electron transport chain and this action is responsible for recent reports of citrinin's apoptotic activity.

Allgemeine Beschreibung

Citrinin is a hepato-nephrotoxic mycotoxin. It can be produced by several filamentous fungi genera of Monauscus, Aspergillus, and Penicillium, which is commonly found as a contaminant in stored grains, foods, feedstuffs and also in biological fluids.

m?gliche Exposition

Specific uses for antimycin A were not found, however, antimycin A1, and antimycin A3 are reported to be antibiotic substances produced by streptomyces for use as a fungicide, possible insecticide and miticide. Registered as a pesticide in the U.S.

Versand/Shipping

UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxo-benzo(c)pyran-7-carbons?ure Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxo-benzo(c)pyran-7-carbons?ure Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 180)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mujin Biotechnology Co.,Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12832 58
Hebei Yanxi Chemical Co., Ltd.
+8617531153977
allison@yan-xi.com China 5857 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18148 58
hebei hongtan Biotechnology Co., Ltd
+86-86-1913198-3935 +8617331935328
sales03@chemcn.cn China 970 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Shanghai Standard Technology Co., Ltd.
18502101150
ft-sales@nature-standard.com CHINA 1923 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29810 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58

518-75-2(3,4-Dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxo-benzo(c)pyran-7-carbons?ure)Verwandte Suche:


  • CITRININ
  • CITRININ, PENICILLIUM CITRINUM
  • 4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC
  • 4,6-DIHYDRO-8-HYDROXY-3,4,5-TRIMETHYL-6-OXO-3H-2-BENZOPYRAN-7-CARBOXYLIC ACID
  • (3r,4s)-4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carbox
  • 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R,4S)-
  • CITRININE
  • Antimycin, Citrinin
  • (3R)-3α,4β,5-Trimethyl-6-oxo-8-hydroxy-3,4-dihydro-6H-2-benzopyran-7-carboxylic acid
  • (3R)-4,6-Dihydro-8-hydroxy-3α,4β,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
  • (3R,4S)-3,4,5-Trimethyl-6-oxo-8-hydroxy-4,6-dihydro-3H-2-benzopyran-7-carboxylic acid
  • Citrinin,98%
  • CITRININ(RG)
  • Citrinin,4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
  • Anti-CTRO antibody produced in rabbit
  • CTRO
  • KIAA0949
  • Rho-interacting
  • Cltrinin
  • MeleaMycin, AntiMycin, Monascidin A
  • Citrinin solution
  • (3R,4S)-4,6-Dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3H-2-benzopyran-7-carboxylic acid
  • ,(3r-trans)-
  • 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-
  • 3H-2-Benzopyran-7-carboxylic acid, 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-, (3R-trans)-
  • 4,6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-3h-2-benzopyran-7-carboxylicaci
  • 6-dihydro-8-hydroxy-3,4,5-trimethyl-6-oxo-(3r-trans)-3h-2-benzopyran-7-carboxylicaci
  • 8-Hydroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid
  • Citriain
  • citrinin,antimycin
  • 3,4-dihydro-8-hydroxy-3,4,5-trimethyl-6H-6-oxobenzo(c)pyran-7-carboxylic acid
  • CITRININ FROM PENICILLIUM CITRINUM
  • Cytrinine
  • TIANFUCHEM--High purity CITRININ factory price
  • CITRININ USP/EP/BP
  • NSC 186
  • (-)-Citrini
  • -Carbomethoxy-3ß
  • -(4-iodophenyl)nortropane (nor-ß
  • (-)-2ß
  • Citrinin, 100ppm
  • ANTIMYCIN
  • CIT
  • 13C13]-Citrinin-10 μg/mL in ACN
  • (-)-Citrini
  • (3R,4S)-8-Hdroxy-3,4,5-trimethyl-6-oxo-4,6-dihydro-3H-isochromene-7-carboxylic acid
  • Citrinin in acetonitrile
  • CITRININ(RG) 5mg
  • Citrinin, tubulin polymerization inhibitor
  • 518-75-2
  • C13H14O5
  • antibiotic
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Active Pharmaceutical Ingredients
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