TALIPEXOLE Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Domin was launched in Japan for Parkinson's disease. The compound is readily accessible in two steps from I-allylhexahydro-4H-azepin4-one. Its antiparkinson activity resides in the fact that talipexole is a selective agonist for presynaptic dopamine D₂ receptors with no D₁ receptor activity. It is a clonidine-like α₂-adrenoreptor agonist and has fewer GI side effects than bromocriptine the most widely used dopamine angonist. Also it is 70 times more potent than bromocriptine and has a more rapid onset of action. In addition to its anti-tremor activity there was a sedative effect but no emesis. The latter probably a result of talipexole's 5-HT₃ receptor antagonistic activity. Its metabolites have no biological activity, there was no development of tolerence and its effect could be enhanced by L-dopa.

Originator

Boehringer Ingelheim (Germany)

Trademarks

Domin

TALIPEXOLE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

TALIPEXOLE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Shaanxi Dideu Medichem Co. Ltd	+86-029-89586680 +86-18192503167	1026@dideu.com	China	7724	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
TargetMol Chemicals Inc.		support@targetmol.com	United States	38631	58
TargetMol Chemicals Inc.	+8613564774135	zijue.cai@tsbiochem.com	United States	19881	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
LGM Pharma	1-(800)-881-8210	inquiries@lgmpharma.com	United States	2123	70
MedChemexpress LLC	021-58955995	sales@medchemexpress.cn	United States	4861	58
LETOPHARM LIMITED	+86-21-5821 5861	sales@letopharm.com	China	2384	58

101626-70-4()Verwandte Suche:

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• TALIPEXOLE
• 5，6，7，8-Tetrahydro-6-(2-propenyl)-4H-thiazolo[4，5-d]azepin-2-amine
• Domin
• 6-Allyl-2-amino-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepine
• 6-Allyl-5,6,7,8-tetrahydro-4H-thiazolo[4,5-d]azepin-2-amine
• Talipexol
• Talipexol [spanish]
• Talipexolum
• Talipexolum [latin]
• 6-Allyl-5,6,7,8-tetrahydro-4H-[1,3]thiazolo[4,5-d]azepin-2-amine
• TALIPEXOLE USP/EP/BP
• 4H-Thiazolo[4,5-d]azepin-2-amine, 5,6,7,8-tetrahydro-6-(2-propen-1-yl)-
• 101626-70-4