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Retaspimycin

Retaspimycin Struktur
857402-23-4
CAS-Nr.
857402-23-4
Englisch Name:
Retaspimycin
Synonyma:
retamycin;retaspimycin;Unii-bzf2zm0I5z;18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)geldanamycin;Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-
CBNumber:
CB31518530
Summenformel:
C31H45N3O8
Molgewicht:
587.7
MOL-Datei:
857402-23-4.mol

Retaspimycin Eigenschaften

Siedepunkt:
800.9±65.0 °C(Predicted)
Dichte
1.23
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
Powder
pka
10.15±0.70(Predicted)

Sicherheit

Retaspimycin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Retaspimycin is a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of HSP90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis.

Verwenden

Retaspimycin (IPI-504) was previously under development by manufacturer Infinity Pharmaceuticals in conjunction with MedImmune, a part of AstraZeneca. Retaspimycin is a small-molecule inhibitor of heat shock protein 90 (HSP90) with antiproliferative and antineoplastic activities. Retaspimycin binds to and inhibits the cytosolic chaperone functions of HSP90, which maintains the stability and functional shape of many oncogenic signaling proteins and may be overexpressed or overactive in tumor cells. Retaspimycin-mediated inhibition of HSP90 promotes the proteasomal degradation of oncogenic signaling proteins in susceptible tumor cell populations, which may result in the induction of apoptosis. Orphan drug designation was assigned to the compound by the FDA for the treatment of gastrointestinal stromal cancer (GIST). Infinity Pharmaceuticals has discontinued the development of retaspimycin (IPI-504) an inhibitor of the HSP-90) complex, for the treatment of cancer due to lack of efficacy in 1913.

Definition

ChEBI: An ansamycin that is tanespimycin in which the benzoquinone moiety has been reduced to the corresponding hydroquinone. A semi-synthetic analogue of geldanamycin, it is used (generally as the hydrochloride salt) in cancer treatment.

Biologische Aktivit?t

IPI-504 potently inhibits proliferation in several tumor cell lines with 50% inhibition concentration IC50 values ranging from 10-40 nM and has been used for the treatment of gastrointestinal stromal tumors, soft-tissue sarcomas and non-small cell lung cancer.

Retaspimycin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Retaspimycin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 41)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30238 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Hangzhou MolCore BioPharmatech Co.,Ltd.
+86-057181025280; +8617767106207
sales@molcore.com China 49734 58
TargetMol Chemicals Inc.

support@targetmol.com United States 38631 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+86-18791163155 +86-13119157289
13119157289@163.com China 2973 58
TargetMol Chemicals Inc.
+8613564774135
zijue.cai@tsbiochem.com United States 19885 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131957 58
Chembest Research Laboratories Limited +86-21-20908456
sales@BioChemBest.com China 6005 61
Jinan Mingya Medical Technology Co., Ltd. 0531-85828981
864598798@qq.com China 588 58

857402-23-4()Verwandte Suche:


  • retaspimycin
  • 18,21-Didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propenylamino)geldanamycin
  • Unii-bzf2zm0I5z
  • Geldanamycin, 18,21-didehydro-17-demethoxy-18,21-dideoxo-18,21-dihydroxy-17-(2-propen-1-ylamino)-
  • retamycin
  • 857402-23-4
  • C31H45N3O8
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