5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Na_v1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel with high activation threshold and slow inactivating kinetics that is highly expressed in small-diameter sensory neurons and has been implicated in signaling various types of pain. A-803467 is a sodium channel blocker with high-affinity and selectivity for inhibiting human Na_v1.8 sodium channels (IC₅₀ = 8 nM when stimulated at half-maximal inactivation and IC₅₀ = 79 nM at a resting state). This compound is unusual in that it blocks hNav1.8 at negative resting membrane potentials (many small molecule sodium channel blockers show a reduced affinity for the resting state) and does not demonstrate significant frequency-dependent block during a 10 Hz pulse train. A-803467 dose-dependently reduces behavioral responses in a variety of neuropathic and inflammatory pain models.

Chemische Eigenschaften

White Solid

Allgemeine Beschreibung

The small molecule A-803467 is a potent and selective Nav1.8 sodium channel blocker. Nav1.8 is a tetrodotoxin-resistant (TTX-R) sodium channel that contributes to pain sensation by transmitting pain stimuli in peripheral sensory neurons; blockage of this channel by A-803467 reduces pain with varying effectiveness in a number of different models. A-803467 has been used to further understand the role of Nav1.8 in transmitting pain stimuli and also can be used as an analgesic.

Biologische Aktivit?t

Selective blocker of Na V 1.8 channels (IC 50 values are 8, 2450, 6740, 7340 and 7380 nM for hNa V 1.8, hNa V 1.3, hNa V 1.7, hNa V 1.5 and hNa V 1.2 channels respectively). Shows no significant activity against TRPV1, P2X 2/3 , Ca V 2.2 and KCNQ2/3 channels. Antinociceptive; potently attenuates mechanical allodynia in two models of neuropathic pain following i.p. administration.

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
-dimethoxyphenylamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Hangzhou FandaChem Co.,Ltd.	+8615858145714	FandaChem@Gmail.com	China	9215	55
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32951	60
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29884	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32079	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	22883	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58

944261-79-4()Verwandte Suche:

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• 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
  -dimethoxyphenylamide
• 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-2-furancarboxamide
• A 803467
• 5-(4-Chlorophenyl)-N-(3,5-dimethoxyphenyl)-
• 5-4(-Chlorophenyl)-N-(3,5-diMethoxyphenyl)furan-2-carboxaMide
• 2-FurancarboxaMide,5-(4-chlorophenyl)-N-(3,5-diMethoxyphenyl)-
• 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5
• A-803467, >=99%
• A803467;A 803467
• 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5lt
• brgt
• -dimethoxyphenylamide
• A-803467, >98%
• CS-374
• [3H]-A-803467
• 5-(4-Chlorophenyl)-furan-2-carboxylic acid 3,5-dimethoxyphenylamide USP/EP/BP
• 944261-79-4
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• Aromatics
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• Sodium channel