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bisphosphonates

bisphosphonates Struktur
CAS-Nr.
Englisch Name:
bisphosphonates
Synonyma:
bisphosphonates
CBNumber:
CB31448242
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

bisphosphonates Eigenschaften

Sicherheit

bisphosphonates Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften

The bisphosphonates have a common structure, P-C-P, which is similar to the structure of the native pyrophosphate P-O-P found in bone hydroxyapatite. The different compounds in clinical use vary by the attachments to the R component of the native molecule.

Indications

The bisphosphonates are synthetic organic compounds that are incorporated directly into the hydroxyapatite of bone and then inhibit osteoclastic bone resorption. This antiresorptive action makes them useful in the pharmacological treatment of hypercalcemia, osteoporosis, and Paget’s disease.

Mechanism of action

The bisphosphonates inhibit osteoclastic resorption of bone by binding to the hydroxyapatite crystals of bone. When osteoclasts first attach to bone in the active resorptive sites, the bisphosphonates are released from that bone. The release of these compounds locally prevents further osteoclastic attachment to those resorptive surfaces. The bisphosphonates also may inhibit resorption by inducing apoptosis of osteoclasts and by inhibiting release of interleukins and other compounds involved in bone resorption. The net result of actions of these compounds is inhibition of bone osteoclastic resorption. This action allows new bone formation to catch up in the remodeling process and can result in a net gain in bone density.

bisphosphonates Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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