bisphosphonates Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
The bisphosphonates have a common structure, P-C-P,
which is similar to the structure of the native pyrophosphate
P-O-P found in bone hydroxyapatite. The different
compounds in clinical use vary by the attachments
to the R component of the native molecule.
Indications
The bisphosphonates are synthetic organic compounds
that are incorporated directly into the hydroxyapatite
of bone and then inhibit osteoclastic bone resorption.
This antiresorptive action makes them useful in the
pharmacological treatment of hypercalcemia, osteoporosis,
and Paget’s disease.
Mechanism of action
The bisphosphonates inhibit osteoclastic resorption of
bone by binding to the hydroxyapatite crystals of bone.
When osteoclasts first attach to bone in the active resorptive
sites, the bisphosphonates are released from that
bone. The release of these compounds locally prevents
further osteoclastic attachment to those resorptive surfaces.
The bisphosphonates also may inhibit resorption by
inducing apoptosis of osteoclasts and by inhibiting release
of interleukins and other compounds involved in bone resorption.
The net result of actions of these compounds is
inhibition of bone osteoclastic resorption. This action allows
new bone formation to catch up in the remodeling
process and can result in a net gain in bone density.
bisphosphonates Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte