Rolipram
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- CAS-Nr.
- 61413-54-5
- Bezeichnung:
- Rolipram
- Englisch Name:
- ROLIPRAM
- Synonyma:
- 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE;ROLIPRAM;SB 95952;ZK-62711;Roliprame;(¨¤)-Rolipr;Rolipram >ROLIPRAM 98+%;(R,S)-Rolipram;Rolipram, >=97%
- CBNumber:
- CB2703866
- Summenformel:
- C16H21NO3
- Molgewicht:
- 275.34
- MOL-Datei:
- 61413-54-5.mol
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Rolipram Eigenschaften
- Schmelzpunkt:
- 127-133 °C
- Siedepunkt:
- 418.29°C (rough estimate)
- Dichte
- 1.0677 (rough estimate)
- Brechungsindex
- 1.5500 (estimate)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- H2O: 0.2 mg/mL
- Aggregatzustand
- solid
- pka
- 16.02±0.40(Predicted)
- Farbe
- white to off-white
- Merck
- 14,8251
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
Rolipram Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Yellowish solid
Verwenden
(±)-Rolipram is a cAMP-specific phosphodiesterase 4 (PDE4) inhibitor.
Allgemeine Beschreibung
A cell-permeable, selective inhibitor of cAMP-specific phosphodiesterase (PDE IV; IC
50 = 800 nM). A rolipram-insensitive PDE IV subtype is also known to exist. Also inhibits NF-κB and NFAT activation in Jurkat and primary T cells.
Biologische Aktivit?t
Selective inhibitor of cAMP phosphodiesterase (PDE4) (IC 50 = 2.0 μ M). Discriminates between two conformational states of PDE4 isoenzymes. See separate isomers ((R)-(-)-Rolipram and (S)-(+)-Rolipram).
Rolipram Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Rolipram Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 190)Lieferanten
61413-54-5(Rolipram)Verwandte Suche:
- ROLIPRAM 98+%
- Roliprame
- 2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
- SB 95952
- 4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone, ZK62711
- 4-[3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL]-2-PYRROLIDINONE
- (R,S)-Rolipram
- ZK-62711, SB95952, ME-3167
- Rolipram, >=97%
- ROLIPRAM
- PYRROLIDIN-2-ONE, 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)- (+/-)
- ZK-62711
- 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-pyrrolidinon
- SB95952;ZK62711;(R;S)-ROLIPRAM;SB 95952;ZK 62711;SB-95952;ZK-62711
- Rolipram - CAS 61413-54-5 - Calbiochem
- Rolipram, 98%, a PDE4 inhibitor
- Rolipram >
- Rolipram Rolipram
- ROLIPRAM USP/EP/BP
- Rolipram - CAS 61413-54-5
- Rolipram (ME 3167
- RolipramQ: What is
Rolipram Q: What is the CAS Number of
Rolipram Q: What is the storage condition of
Rolipram Q: What are the applications of
Rolipram
- 4-(3-(CYCLOPENTYLOXY)-4-METHOXYPHENYL)PYRROLIDIN-2-ONE
- Rolipram (ZK-62711)
- (¨¤)-Rolipr
- 61413-54-5
- C16H21NO3
- BioChemical
- Cell Biology
- Cell Signaling and Neuroscience
- Cyclic Nucleotide Metabolism
- G Proteins and Cyclic Nucleotides
- Phosphodiesterase Inhibitors
- Inhibitor
- DIPIPERON
- Inhibitors
- Antineoplastic
- Cyclic Nucleotide related
- Signalling
